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| Registros recuperados : 151 | |
| Registros recuperados : 151 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
21/11/2017 |
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Data da última atualização: |
29/12/2017 |
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Autoria: |
ALMEIDA, A. C.; ANDRADE, V. A.; FONSECA, F. S. A.; MACÊDO, A. A.; SANTOS, R. L.; COLEN, K. G. F.; MARTINS, E. R.; MARCELO, N. A. |
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Afiliação: |
Anna C. Almeida, Instituto de Ciências Agrárias/Universidade Federal de Minas Gerais - UFMG; Viviane A. Andrade, Instituto Federal do Norte de Minas Gerais - IFNMG; Francine S. A. Fonseca, Instituto de Ciências Agrárias/Universidade Federal de Minas Gerais - UFMG; Auricélio A. Macêdo, Departamento de Clínica e Cirugia/Escola de Veterinária - UFMG; Renato L. Santos, Departamento de Clínica e Cirugia/Escola de Veterinária - UFMG; Keila G. F. Colen, Instituto de Ciências Agrárias/Universidade Federal de Minas Gerais - UFMG; Ernane R. Martins, Instituto de Ciências Agrárias/Universidade Federal de Minas Gerais - UFMG; Natália A. Marcelo, Instituto de Ciências Agrárias/Universidade Federal de Minas Gerais - UFMG. |
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Título: |
Acute and chronic toxicity and antimicrobial activity of the extract of Stryphnodendron adstringens (Mart.) Coville. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 8, p. 840-846, ago. 2017. |
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Idioma: |
Inglês |
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Notas: |
Título em português: Toxicidade aguda e crônica e atividade antimicrobiana do extrato de Stryphnodendron adstringens (Mart.) Coville. |
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Conteúdo: |
This study evaluated the antimicrobial activity and acute or chronic toxicity of the extract of Stryphnodendron adstringens. The stem bark dry extract was obtained by static maceration with ethanol. Quantification of tannins was performed by the Folin-Denis method, which indicated a total tannin content of 32.7%. The antimicrobial activity of the dry extract of S. adstringens was evaluated by agar-based disk diffusion assay with Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923) in the concentration of 200, 400 and 600?L/mL. The results indicated that 600?L/mL inhibited microbial growth, i.e. had antimicrobial activity against these species. Acute and chronic toxic effects of S. adstringens was evaluated in Wistar rats treated with 200, 400, 600 and 800mg/kg of extract, administrated by gavage. Liver degeneration was observed in the group of rats receiving 800mg/kg in chronic exposure, what may indicate some degree of toxicity at this concentration. However, no systemic toxicity was observed at lower doses. Considering the broad use of S. adstringens as a phytotherapeutic agent for various human and animal diseases and the livertoxicity observed at high concentrations, attention should be paid to the possible adverse effect of using the extract from this plant at high concentration. |
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Palavras-Chave: |
Antimicrobial activity; Atividade antimicrobiana; Hematological parameters; Parâmetro bioquímico; Parâmetro hematológico; Stryphnodendron adstringens; Taninos; Toxicidade hepática. |
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Thesagro: |
Barbatimão; Extrato; Toxidez. |
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Thesaurus NAL: |
Blood chemistry; Extracts; Hepatotoxicity; Tannins; Toxicity. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/167161/1/Acute-and-chronic-toxicity-and-antimicrobial.pdf
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Marc: |
LEADER 02662naa a2200409 a 4500
001 2080311
005 2017-12-29
008 2017 bl uuuu u00u1 u #d
100 1 $aALMEIDA, A. C.
245 $aAcute and chronic toxicity and antimicrobial activity of the extract of Stryphnodendron adstringens (Mart.) Coville.$h[electronic resource]
260 $c2017
500 $aTítulo em português: Toxicidade aguda e crônica e atividade antimicrobiana do extrato de Stryphnodendron adstringens (Mart.) Coville.
520 $aThis study evaluated the antimicrobial activity and acute or chronic toxicity of the extract of Stryphnodendron adstringens. The stem bark dry extract was obtained by static maceration with ethanol. Quantification of tannins was performed by the Folin-Denis method, which indicated a total tannin content of 32.7%. The antimicrobial activity of the dry extract of S. adstringens was evaluated by agar-based disk diffusion assay with Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923) in the concentration of 200, 400 and 600?L/mL. The results indicated that 600?L/mL inhibited microbial growth, i.e. had antimicrobial activity against these species. Acute and chronic toxic effects of S. adstringens was evaluated in Wistar rats treated with 200, 400, 600 and 800mg/kg of extract, administrated by gavage. Liver degeneration was observed in the group of rats receiving 800mg/kg in chronic exposure, what may indicate some degree of toxicity at this concentration. However, no systemic toxicity was observed at lower doses. Considering the broad use of S. adstringens as a phytotherapeutic agent for various human and animal diseases and the livertoxicity observed at high concentrations, attention should be paid to the possible adverse effect of using the extract from this plant at high concentration.
650 $aBlood chemistry
650 $aExtracts
650 $aHepatotoxicity
650 $aTannins
650 $aToxicity
650 $aBarbatimão
650 $aExtrato
650 $aToxidez
653 $aAntimicrobial activity
653 $aAtividade antimicrobiana
653 $aHematological parameters
653 $aParâmetro bioquímico
653 $aParâmetro hematológico
653 $aStryphnodendron adstringens
653 $aTaninos
653 $aToxicidade hepática
700 1 $aANDRADE, V. A.
700 1 $aFONSECA, F. S. A.
700 1 $aMACÊDO, A. A.
700 1 $aSANTOS, R. L.
700 1 $aCOLEN, K. G. F.
700 1 $aMARTINS, E. R.
700 1 $aMARCELO, N. A.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 37, n. 8, p. 840-846, ago. 2017.
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Embrapa Unidades Centrais (AI-SEDE) |
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