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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
Registro Completo |
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
01/08/1992 |
Data da última atualização: |
23/06/2023 |
Autoria: |
SWIFT, A. D.; CRIGHTON, D. B. |
Título: |
Relative activity plasma elimination and tissue degradation of synthetic luteinizing hormone releasing hormone and certain of its analogues. |
Ano de publicação: |
1979 |
Fonte/Imprenta: |
Journal of Endocrinology, v. 80, n. 1, p. 141-152, 1979. |
DOI: |
1677/joe.0.0800141. |
Idioma: |
Inglês |
Conteúdo: |
Abstract: The abilities of three nonapeptide analogues of synthetic luteinizing hormone releasing hormone (LH-RH) to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in anoestrous and cyclic ewes were examined, as were their elimination from the plasma in vivo and degradation by extracts of the hypothalamus, anterior pituitary gland, lung, kidney, liver and plasma in vitro. In all cases, comparisons were made with synthetic LH-RH. When injected i.v. into mature ewes as a single dose, the potencies of the analogues were graded and Des Gly-NH2(10) LH-RH ethylamide was found to be the least potent. It was not possible to demonstrate any significant increase in the potency of this analogue over LH-RH, although a trend was apparent with each parameter examined. [D-Ser(But)6] Des Gly-NH2(10) LH-RH ethylamide had the greatest potency. There were no differences between the responses of anoestrous ewes and those of ewes treated on day 10 of the oestrous cycle. None of the analogues had a rate of elimination from the plasma different from that of LH-RH during either the first or the second components of the biphasic disappearance curve. The incubation of LH-RH with tissue extracts showed that extracts of the hypothalamus and anterior pituitary gland degraded LH-RH to a similar extent. Both the hypothalamic and anterior pituitary gland extracts degraded more LH-RH than did lung extract, which in turn destroyed more LH-RH than did extracts of kidney or liver tissue. The degradative abilities of kidney and liver extracts did not differ from each other. Plasma failed to degrade LH-RH or the analogues. Although LH-RH was rapidly destroyed by hypothalamic extract in vitro, of the analogues, only Des Gly-NH2(10) LH-RH ethylamide was degraded. The anterior pituitary gland and kidney extracts failed to degrade [D-Ser6] Des Gly-NH2(10) LH-RH ethylamide and [D-Ser(But)6] Des Gly-NH2(10) LH-RH ethylamide as rapidly as LH-RH. Extracts of liver and lung were incapable of catabolizing any of the analogues. There was an inverse correlation between the LH- and FSH-releasing potency of an analogue and its rate of degradation by anterior pituitary gland extract. The slower rates of catabolism of certain analogues of LH-RH by the anterior pituitary gland may explain their increased LH- and FSH-releasing potency. MenosAbstract: The abilities of three nonapeptide analogues of synthetic luteinizing hormone releasing hormone (LH-RH) to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in anoestrous and cyclic ewes were examined, as were their elimination from the plasma in vivo and degradation by extracts of the hypothalamus, anterior pituitary gland, lung, kidney, liver and plasma in vitro. In all cases, comparisons were made with synthetic LH-RH. When injected i.v. into mature ewes as a single dose, the potencies of the analogues were graded and Des Gly-NH2(10) LH-RH ethylamide was found to be the least potent. It was not possible to demonstrate any significant increase in the potency of this analogue over LH-RH, although a trend was apparent with each parameter examined. [D-Ser(But)6] Des Gly-NH2(10) LH-RH ethylamide had the greatest potency. There were no differences between the responses of anoestrous ewes and those of ewes treated on day 10 of the oestrous cycle. None of the analogues had a rate of elimination from the plasma different from that of LH-RH during either the first or the second components of the biphasic disappearance curve. The incubation of LH-RH with tissue extracts showed that extracts of the hypothalamus and anterior pituitary gland degraded LH-RH to a similar extent. Both the hypothalamic and anterior pituitary gland extracts degraded more LH-RH than did lung extract, which in turn destroyed more LH-RH than did extracts of kidney or liver tissu... Mostrar Tudo |
Palavras-Chave: |
FSH; Hormônio luteinizante. |
Thesagro: |
Endocrinologia; Fisiologia; Ovino; Reprodução. |
Thesaurus Nal: |
Endocrinology; Follicle-stimulating hormone; Luteinizing hormone; Reproduction; Sheep; Synthetic hormones. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
Marc: |
LEADER 03226naa a2200289 a 4500 001 1522049 005 2023-06-23 008 1979 bl uuuu u00u1 u #d 024 7 $a1677/joe.0.0800141.$2DOI 100 1 $aSWIFT, A. D. 245 $aRelative activity plasma elimination and tissue degradation of synthetic luteinizing hormone releasing hormone and certain of its analogues.$h[electronic resource] 260 $c1979 520 $aAbstract: The abilities of three nonapeptide analogues of synthetic luteinizing hormone releasing hormone (LH-RH) to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in anoestrous and cyclic ewes were examined, as were their elimination from the plasma in vivo and degradation by extracts of the hypothalamus, anterior pituitary gland, lung, kidney, liver and plasma in vitro. In all cases, comparisons were made with synthetic LH-RH. When injected i.v. into mature ewes as a single dose, the potencies of the analogues were graded and Des Gly-NH2(10) LH-RH ethylamide was found to be the least potent. It was not possible to demonstrate any significant increase in the potency of this analogue over LH-RH, although a trend was apparent with each parameter examined. [D-Ser(But)6] Des Gly-NH2(10) LH-RH ethylamide had the greatest potency. There were no differences between the responses of anoestrous ewes and those of ewes treated on day 10 of the oestrous cycle. None of the analogues had a rate of elimination from the plasma different from that of LH-RH during either the first or the second components of the biphasic disappearance curve. The incubation of LH-RH with tissue extracts showed that extracts of the hypothalamus and anterior pituitary gland degraded LH-RH to a similar extent. Both the hypothalamic and anterior pituitary gland extracts degraded more LH-RH than did lung extract, which in turn destroyed more LH-RH than did extracts of kidney or liver tissue. The degradative abilities of kidney and liver extracts did not differ from each other. Plasma failed to degrade LH-RH or the analogues. Although LH-RH was rapidly destroyed by hypothalamic extract in vitro, of the analogues, only Des Gly-NH2(10) LH-RH ethylamide was degraded. The anterior pituitary gland and kidney extracts failed to degrade [D-Ser6] Des Gly-NH2(10) LH-RH ethylamide and [D-Ser(But)6] Des Gly-NH2(10) LH-RH ethylamide as rapidly as LH-RH. Extracts of liver and lung were incapable of catabolizing any of the analogues. There was an inverse correlation between the LH- and FSH-releasing potency of an analogue and its rate of degradation by anterior pituitary gland extract. The slower rates of catabolism of certain analogues of LH-RH by the anterior pituitary gland may explain their increased LH- and FSH-releasing potency. 650 $aEndocrinology 650 $aFollicle-stimulating hormone 650 $aLuteinizing hormone 650 $aReproduction 650 $aSheep 650 $aSynthetic hormones 650 $aEndocrinologia 650 $aFisiologia 650 $aOvino 650 $aReprodução 653 $aFSH 653 $aHormônio luteinizante 700 1 $aCRIGHTON, D. B. 773 $tJournal of Endocrinology$gv. 80, n. 1, p. 141-152, 1979.
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Embrapa Caprinos e Ovinos (CNPC) |
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Biblioteca(s): |
Embrapa Uva e Vinho. |
Data corrente: |
20/12/2018 |
Data da última atualização: |
12/05/2022 |
Tipo da produção científica: |
Artigo em Anais de Congresso |
Autoria: |
ROSA, J. M. da; ARIOLI, C. J.; AGOSTINETTO, L.; PADILHA, A. C.; BOTTON, M. |
Afiliação: |
Joatan Machado da Rosa, Eng. Agr. MSc. Doutorando em Fitossanidade, UFPel; joatanmachado@gmail.com; Cristiano João Arioli, Dr. Pesquisador, Empresa de Pesquisa e Extensão Rural de Santa Catarina (Epagri). cristianoarioli@epagri.sc.gov.br; Lenita Agostinetto, Dra. Prof. de pós - graduação em Ambiente e Saúde, Uniplac, leagostinetto@yahoo.com.br; Aline Costa Padilha, Eng. Agr. MSc. Doutorando em Fitossanidade, UFPel; joatanmachado@gmail.com; MARCOS BOTTON, CNPUV. |
Título: |
Efeito de atrativos alimentares na captura da mosca-das-frutas, Anastrepha fraterculus em pomar de goiabeira serrana. |
Ano de publicação: |
2015 |
Fonte/Imprenta: |
In: SIMPÓSIO INTERNACIONAL CIÊNCIA, SAÚDE E TERRITÓRIO, 3., COLÓQUIO DE EDUCAÇÃO PERMANENTE, 2., 2015. Anais... Saúde no ambiente Rural e Urbano, Lages, SC: Uniplac, 2015. p. 383-390, Artigo 24899. |
Idioma: |
Português |
Conteúdo: |
A espécie Acca sellowiana(Berg) Burret, conhecida comumente como goiabeira serrana, goiaba-do-mato, goiaba-do-campo, feijoa e na língua inglesa como pineapple-guava é uma frutífera nativa da América do sul, ocorrendo principalmente no planalto meridional brasileiro e no Uruguai (Ducroquet et al. 2000). |
Palavras-Chave: |
Atrativo alimentar; Goiaba-do-campo; Goiaba-do-mato; Goiabeira serrana. |
Thesagro: |
Alimento; Atrativo; Goiaba Serrana; Mosca das Frutas. |
Thesaurus NAL: |
Acca sellowiana. |
Categoria do assunto: |
-- |
URL: |
https://www.alice.cnptia.embrapa.br/alice/bitstream/doc/1102254/1/AnaisIIISimposioInternacionalCienciaSaudeTerritorio201524899.pdf
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Marc: |
LEADER 01261nam a2200265 a 4500 001 2102254 005 2022-05-12 008 2015 bl uuuu u00u1 u #d 100 1 $aROSA, J. M. da 245 $aEfeito de atrativos alimentares na captura da mosca-das-frutas, Anastrepha fraterculus em pomar de goiabeira serrana.$h[electronic resource] 260 $aIn: SIMPÓSIO INTERNACIONAL CIÊNCIA, SAÚDE E TERRITÓRIO, 3., COLÓQUIO DE EDUCAÇÃO PERMANENTE, 2., 2015. Anais... Saúde no ambiente Rural e Urbano, Lages, SC: Uniplac, 2015. p. 383-390, Artigo 24899.$c2015 520 $aA espécie Acca sellowiana(Berg) Burret, conhecida comumente como goiabeira serrana, goiaba-do-mato, goiaba-do-campo, feijoa e na língua inglesa como pineapple-guava é uma frutífera nativa da América do sul, ocorrendo principalmente no planalto meridional brasileiro e no Uruguai (Ducroquet et al. 2000). 650 $aAcca sellowiana 650 $aAlimento 650 $aAtrativo 650 $aGoiaba Serrana 650 $aMosca das Frutas 653 $aAtrativo alimentar 653 $aGoiaba-do-campo 653 $aGoiaba-do-mato 653 $aGoiabeira serrana 700 1 $aARIOLI, C. J. 700 1 $aAGOSTINETTO, L. 700 1 $aPADILHA, A. C. 700 1 $aBOTTON, M.
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