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Registro Completo |
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Biblioteca(s): |
Embrapa Soja. |
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Data corrente: |
10/01/2011 |
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Data da última atualização: |
19/05/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MARCARINI, J. C.; TSUBOY, M. S. F.; LUIZ, R. C.; RIBEIRO, L. R.; HOFFMANN-CAMPO, C. B.; MANTOVANI, M. S. |
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Afiliação: |
JULIANA CRISTINA MARCARINI, UEL; MARCELA STEFANINI FERREIRA TSUBOY, UEL; RODRIGO CABRAL LUIZ, UEL; LUCIA REGINA RIBEIRO, UNESP; CLARA BEATRIZ HOFFMANN CAMPO, CNPSO; MÁRIO SÉRGIO MANTOVANI, UEL. |
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Título: |
Investigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Experimental and Toxicologic Pathology, v. 63, n. 5, p. 459-465, 2011. |
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DOI: |
10.1016/j.etp.2010.03.005 |
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Idioma: |
Inglês |
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Conteúdo: |
Rutin isaflavonoid with antioxidant, vasodilatory, anti-inflammatory and immune-stimulating activities. To study the toxicity of rutin and its protective effect, this work investigated the cytotoxic, apoptosis-inducing, genotoxic and protective effects of rutinin HTCcells. In the MTT assay, the highest concentration tested (810 mM) showed cytotoxicity after 72 h of treatment,where cell viability and cell proliferation was diminished. None of the concentration sof rutin tested induced apoptosis after 24 h treatment. The highest concentration of rutin after 24 h treatment induced DNA damage, shown in the comet assay,but did have a genotoxic effect in the micronucleus test. Rutin wastested against the pro-carcinogenic agent benzo(a)pyrene, at concentrations of 90, 270 and 810 mM, and was found to reduce induced DNA damage significantly.This protective effect of rutin against apro-carcinogen, suggests an important biological activity for this compound, whichc an contribute to human health through the diet. |
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Thesagro: |
Citogenetica; Flavonoide; Toxidez. |
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Thesaurus Nal: |
Cytotoxicity; Flavonoids. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
null
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Registro original: |
Embrapa Soja (CNPSO) |
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