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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
28/11/2014 |
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Data da última atualização: |
05/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
O'BRIEN, A. M. P.; MÉSZÁROS, G.; UTSUNOMIYA, Y. T.; SONSTEGARD, T. S.; GARCIA, J. F.; TASSEL, C. P. V.; CARVALHEIRO, R.; SILVA, M. V. G. B.; SÖLKNER, J. |
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Afiliação: |
ANA M. PÉREZ O'BRIEN, University of Natural Resources and Life Sciences, Vienna; GÁBOR MÉSZÁROS, University of Natural Resources and Life Sciences, Vienna; YURI T. UTSUNOMIYA, UNESP; TAD S. SONSTEGARD, ARS-USDA, USA; JOSÉ F. GARCIA, UNESP; CURTIS P. VAN TASSEL, ARS-USDA, USA; ROBERTO CARVALHEIRO, GenSys Consultores Associados; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; JOHANN SÖLKNER, University of Natural Resources and Life Sciences, Vienna. |
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Título: |
Linkage disequilibrium levels in Bos indicus and Bos taurus cattle using medium and high density SNP chip data and different minor allele frequency distributions. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Livestock Science, v. 166, p. 121-132, 2014. |
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Idioma: |
Inglês |
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Conteúdo: |
Linkage disequilibrium (LD), the observed correlation between alleles at different loci in the genome, is a determinant parameter in many applications of molecular genetics. With the wider use of genomic technologies in animal breeding and animal genetics, it is worthwhile revising and improving the current knowledge and understanding of cattle LD. This study analyzes levels of LD assessed through the r2 measurement in seven breeds of cattle from both indicine (Bos indicus) and taurine (Bos taurus) (sub)species, genotyped with a high density panel (HD) of over 777,000 single nucleotide polymorphism (SNP) markers. Average levels of LD were assessed for inter-marker distances from 0 kb up to 10 Mb. Two more SNP panels were built in silico from the original genotypes to represent a lower density SNP chip including approximately 50,000 SNPs (50K) and a panel of 249,000 SNPs chosen to comply with specific minor allele frequency (MAF) distributions. The results show higher levels of LD than previously reported, especially at short inter-marker distances of less than 20 kb, assessed through the use of the higher density panel. Negligible impact of MAF changes in the estimation of r2 was observed, supporting the use of the HD panel for LD-based methodologies even when ascertainment bias in the choice of SNPs is suspected. The 50K SNP panel indicated lower levels of LD in the first 100 kb and highly unreliable LD estimates for distances shorter than 50 kb. Overall, lower levels of LD were observed for all indicine breeds as compared to taurine breeds, with larger differences assessed in the first 100 kb, suggesting the need for use of higher SNP densities in this (sub)species when applying LD-dependent methods, as compared to most taurine breeds. MenosLinkage disequilibrium (LD), the observed correlation between alleles at different loci in the genome, is a determinant parameter in many applications of molecular genetics. With the wider use of genomic technologies in animal breeding and animal genetics, it is worthwhile revising and improving the current knowledge and understanding of cattle LD. This study analyzes levels of LD assessed through the r2 measurement in seven breeds of cattle from both indicine (Bos indicus) and taurine (Bos taurus) (sub)species, genotyped with a high density panel (HD) of over 777,000 single nucleotide polymorphism (SNP) markers. Average levels of LD were assessed for inter-marker distances from 0 kb up to 10 Mb. Two more SNP panels were built in silico from the original genotypes to represent a lower density SNP chip including approximately 50,000 SNPs (50K) and a panel of 249,000 SNPs chosen to comply with specific minor allele frequency (MAF) distributions. The results show higher levels of LD than previously reported, especially at short inter-marker distances of less than 20 kb, assessed through the use of the higher density panel. Negligible impact of MAF changes in the estimation of r2 was observed, supporting the use of the HD panel for LD-based methodologies even when ascertainment bias in the choice of SNPs is suspected. The 50K SNP panel indicated lower levels of LD in the first 100 kb and highly unreliable LD estimates for distances shorter than 50 kb. Overall, lower levels of LD... Mostrar Tudo |
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Palavras-Chave: |
Indicine; Minor allele frequency. |
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Thesaurus Nal: |
cattle; linkage disequilibrium; taurine. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
null
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 3 | |
| 1. |  | FARIA, D. A. de; BORBA FILHO, A. B.; MATOS, V. A. T. de; CARVALHO, E. A. de; CARVALHO, C. G. P. características agronômicas de genótipos de girassol cultivados em campo verde - mt, na safrinha de 2016. In: REUNIÃO NACIONAL DE PESQUISA DE GIRASSOL, 22.; SIMPÓSIO NACIONAL SOBRE A CULTURA DO GIRASSOL, 10., 2017, Lavras. Anais... Londrina: Embrapa Soja, 2017. p. 125-128. (Embrapa Soja. Documentos, 395). Editado por Regina Maria Villas Bôas de Campos Leite. Título em inglês: Agronomic characteristics of sunflower genotypes cultivated in campo verde - mt, on off-season of 2016.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Soja. |
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| 2. | | AMABILE, R. F.; MATOS, V. A. T.; DALCHIAVON, F. C.; BORBA FILHO, A. B.; ALVES, A. D.; FREITAS, R. J.; ANSELMO, J. L.; SILVA, A. G.; GODINHO, V. de P. C.; CARVALHO, C. G. P. Adaptabilidade e estabilidade de híbridos de girassol de segunda safra de verão no Brasil, anos agrícolas 2016 e 2017. Planaltina, DF : Embrapa Cerrados, 2020. 18 p. (Embrapa Cerrados. Boletim de Pesquisa e Desenvolvimento, 356).| Tipo: Boletim de Pesquisa e Desenvolvimento |
| Biblioteca(s): Embrapa Cerrados; Embrapa Rondônia; Embrapa Soja. |
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| 3. | | ASSIS, R. G. da S.; VIEIRA, L. H.; AMABILE, R. F.; GODINHO, V. de P. C.; MATOS, V. A. T. de; RAMOS, N. P.; SILVA, A. G. da; CARVALHO, C. G. P. Adaptabilidade e estabilidade de híbridos de girassol em segunda safra de verão no Brasil. In: JORNADA ACADÊMICA DA EMBRAPA SOJA, 18., 2023, Londrina. Resumos expandidos... Londrina: Embrapa Soja, 2023. (Embrapa Soja. Documentos, 453). Regina Maria Villas Bôas de Campos Leite, Larissa Alexandra Cardoso Moraes, Kelly Catharin, Editoras Técnicas. p. 120-125.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Cerrados; Embrapa Rondônia; Embrapa Soja. |
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| Registros recuperados : 3 | |
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