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Registro Completo |
Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios. |
Data corrente: |
10/12/2024 |
Data da última atualização: |
03/01/2025 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
FREIRE, G. DE P.; ALMEIDA FILHO, L. C. P.; RIBEIRO, P. R. V.; NUNES, P. I. G.; LIMA, R. P. DE; PORTELA, B. Y. M.; BRITO, E. S. de; ALVES, A. P. N. N.; VIANA, D. DE A.; URANO, C. A. DE F. F.; SANTOS, F. A. |
Afiliação: |
GABRIELLE DE PAULA FREIRE, UNIVERSIDADE FEDERAL DO CEARÁ; LUIZ CARLOS PEREIRA ALMEIDA FILHO, UNIVERSIDADE FEDERAL DO CEARÁ; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; PAULO IURY GOMES NUNES, UNIVERSIDADE FEDERAL DO CEARÁ; RENAN PEREIRA DE LIMA, WEILL CORNELL MEDICINE; BENEDITO YAGO MACHADO PORTELA, UNIVERSIDADE FEDERAL DO CEARÁ; EDY SOUSA DE BRITO, CNAT; ANA PAULA NEGREIROS NUNES ALVES, UNIVERSIDADE FEDERAL DO CEARÁ; DANIEL DE ARAÚJO VIANA, CENTRO UNIVERSITÁRIO CHRISTUS; CARVALHO ANA DE FÁTIMA FONTENELE URANO, UNIVERSIDADE FEDERAL DO CEARÁ; FLAVIA ALMEIDA SANTOS, UNIVERSIDADE FEDERAL DO CEARÁ. |
Título: |
Gastroprotective and ulcer healing efects of Lonchocarpus sericeus seed extract in rodents. |
Ano de publicação: |
2024 |
Fonte/Imprenta: |
Revista Brasileira de Farmacognosia, v. 34, p. 1298–1312, 2024. |
Páginas: |
. |
DOI: |
https://doi.org/10.1007/s43450-024-00577-w |
Idioma: |
Inglês |
Conteúdo: |
Lonchocarpus sericeus (Poir.) Kunth ex DC., Fabaceae, is traditionally used to treat stomach disorders and constipation. Previous studies examined its anti-inflammatory, antinociceptive, and hepatoprotective properties, but its potential as a gastroprotective agent remains unexplored. This study aimed to investigate the gastroprotective and gastric healing effects of the hexane extract of L. sericeus seeds and assess its acute toxicity. Gas chromatography revealed that the hexane extract contains eight fatty acids, with oleic acid, palmitic acid, and behenic acid being the most abundant. In mice, L. sericeus extract (0.8, 1.6, and 3.2 mg/kg, p.o.) significantly reduced gastric lesions induced by ethanol, while a seven-day treatment with the extract (25, 50, and 100 mg/kg, p.o.) significantly reduced lesion area and volume in acetic acid-induced gastric lesions in rats. The extract demonstrated an antioxidant effect in both models. The gastroprotective effect of the extract on ethanol-induced gastric lesions involved the inhibition of signaling pathways related to the stimulation of endogenous prostaglandins and nitric oxide and the activation of TRPV1 receptors but not potassium channels. The extract also protected against ethanol-induced depletion of gastric wall mucus and reduced gastric secretory volume and acidity, while increasing pH in pylorus-ligated mice. Gastric histological analysis revealed that the extract promotes reepithelialization and reduces hemorrhage and inflammation. In conclusion, L. sericeus extract exhibited gastroprotective effects against ethanol- and acetic acid-induced gastric ulcers, likely due to its antioxidant activity, preservation of gastric mucus, regulation of prostaglandins and nitric oxide release, TRPV1 receptors activation, and antisecretory activity, with no observed toxicity. MenosLonchocarpus sericeus (Poir.) Kunth ex DC., Fabaceae, is traditionally used to treat stomach disorders and constipation. Previous studies examined its anti-inflammatory, antinociceptive, and hepatoprotective properties, but its potential as a gastroprotective agent remains unexplored. This study aimed to investigate the gastroprotective and gastric healing effects of the hexane extract of L. sericeus seeds and assess its acute toxicity. Gas chromatography revealed that the hexane extract contains eight fatty acids, with oleic acid, palmitic acid, and behenic acid being the most abundant. In mice, L. sericeus extract (0.8, 1.6, and 3.2 mg/kg, p.o.) significantly reduced gastric lesions induced by ethanol, while a seven-day treatment with the extract (25, 50, and 100 mg/kg, p.o.) significantly reduced lesion area and volume in acetic acid-induced gastric lesions in rats. The extract demonstrated an antioxidant effect in both models. The gastroprotective effect of the extract on ethanol-induced gastric lesions involved the inhibition of signaling pathways related to the stimulation of endogenous prostaglandins and nitric oxide and the activation of TRPV1 receptors but not potassium channels. The extract also protected against ethanol-induced depletion of gastric wall mucus and reduced gastric secretory volume and acidity, while increasing pH in pylorus-ligated mice. Gastric histological analysis revealed that the extract promotes reepithelialization and reduces hemorrhage and i... Mostrar Tudo |
Palavras-Chave: |
TRPV1 receptor activation. |
Thesaurus Nal: |
Antioxidants; Fatty acids; Nitric oxide; Prostaglandins. |
Categoria do assunto: |
W Química e Física |
Marc: |
LEADER 02832naa a2200325 a 4500 001 2170288 005 2025-01-03 008 2024 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1007/s43450-024-00577-w$2DOI 100 1 $aFREIRE, G. DE P. 245 $aGastroprotective and ulcer healing efects of Lonchocarpus sericeus seed extract in rodents.$h[electronic resource] 260 $c2024 300 $a. 520 $aLonchocarpus sericeus (Poir.) Kunth ex DC., Fabaceae, is traditionally used to treat stomach disorders and constipation. Previous studies examined its anti-inflammatory, antinociceptive, and hepatoprotective properties, but its potential as a gastroprotective agent remains unexplored. This study aimed to investigate the gastroprotective and gastric healing effects of the hexane extract of L. sericeus seeds and assess its acute toxicity. Gas chromatography revealed that the hexane extract contains eight fatty acids, with oleic acid, palmitic acid, and behenic acid being the most abundant. In mice, L. sericeus extract (0.8, 1.6, and 3.2 mg/kg, p.o.) significantly reduced gastric lesions induced by ethanol, while a seven-day treatment with the extract (25, 50, and 100 mg/kg, p.o.) significantly reduced lesion area and volume in acetic acid-induced gastric lesions in rats. The extract demonstrated an antioxidant effect in both models. The gastroprotective effect of the extract on ethanol-induced gastric lesions involved the inhibition of signaling pathways related to the stimulation of endogenous prostaglandins and nitric oxide and the activation of TRPV1 receptors but not potassium channels. The extract also protected against ethanol-induced depletion of gastric wall mucus and reduced gastric secretory volume and acidity, while increasing pH in pylorus-ligated mice. Gastric histological analysis revealed that the extract promotes reepithelialization and reduces hemorrhage and inflammation. In conclusion, L. sericeus extract exhibited gastroprotective effects against ethanol- and acetic acid-induced gastric ulcers, likely due to its antioxidant activity, preservation of gastric mucus, regulation of prostaglandins and nitric oxide release, TRPV1 receptors activation, and antisecretory activity, with no observed toxicity. 650 $aAntioxidants 650 $aFatty acids 650 $aNitric oxide 650 $aProstaglandins 653 $aTRPV1 receptor activation 700 1 $aALMEIDA FILHO, L. C. P. 700 1 $aRIBEIRO, P. R. V. 700 1 $aNUNES, P. I. G. 700 1 $aLIMA, R. P. DE 700 1 $aPORTELA, B. Y. M. 700 1 $aBRITO, E. S. de 700 1 $aALVES, A. P. N. N. 700 1 $aVIANA, D. DE A. 700 1 $aURANO, C. A. DE F. F. 700 1 $aSANTOS, F. A. 773 $tRevista Brasileira de Farmacognosia$gv. 34, p. 1298–1312, 2024.
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Registro original: |
Embrapa Agroindústria Tropical (CNPAT) |
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Registros recuperados : 8 | |
1. |  | ROCHA, R. R. C.; COSTA, A. P. R.; AZEVÊDO, D. M. M. R.; NASCIMENTO, H. T. S. do; CARDOSO, F. S.; MURATORI, M. C. S.; LOPES, J. B. Adaptabilidade climática de caprinos saanen e azul no Meio-Norte do Brasil. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 61, n. 5, p. 1165-1172, 2009.Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
Biblioteca(s): Embrapa Meio-Norte. |
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2. |  | PEREIRA, E. J.; CARVALHO, L. M. J.; DELLAMORA-ORTIZ, G. M.; CARDOSO, F. S. N.; CARVALHO, J. L. V.; VIANA, D. S.; FREITAS, S. C.; ROCHA, M. M. Effects of cooking methods on the iron and zinc contents in cowpea (Vigna unguiculata) to combat nutritional deficiencies in Brazil. Food & Nutrition Research, v. 58, 2014.Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 4 |
Biblioteca(s): Embrapa Agroindústria de Alimentos; Embrapa Meio-Norte. |
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4. |  | SANTOS, F. S. M. dos; PIRES, J. E. P.; PEREIRA, A. M.; AZEVEDO, D. M. M. R.; ROCHA, R. R. C.; CARDOSO, F. S.; ARAUJO, A. M.; MURATORI, M. C. S.; COSTA, A. P. R. Adaptabilidade de caprinos Sannen e Marota mantidos em clima tropical semiúmido. Revista Brasileira de Saúde e Produção Animal, Salvador, v. 15, n. 4, p. 928-936, out./dez. 2014. Autoria: ADRIANA MELLO [i.e. DE] ARAUJO.Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
Biblioteca(s): Embrapa Meio-Norte. |
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5. |  | CARVALHO, L. M. J. de; PEREIRA, E. de J.; FREITAS, S. C. de; CARVALHO, J. L. V. de; SANTOS, J. de O.; SIMAS, E. S.; ROCHA, M. de M.; CARDOSO, F.; FIGUEIREDO, R. E. P. Efeito do tratamento térmico sobre a bioacessibilidade de ferro e zinco em feijão-caupi (Vigna unguiculata (L.) Walp.). In: REUNIÃO DE BIOFORTIFICAÇÃO NO BRASIL, 5., 2015, São Paulo. Anais... Brasília, DF: Embrapa, 2015. p. 32-35 T202. Título equivalente: Heat process effect on iron and zinc bioavailability in cowpea (vigna unguiculata (l.) Walp.).Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Agroindústria de Alimentos; Embrapa Meio-Norte. |
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6. |  | ROCHA, R. R. C.; ARAÚJO, A. M. de; COSTA, M. da S.; SOUSA, M. V. S. de; CARDOSO, F. S.; CARVALHO, J. A. G. de; SILVA, D. C. da; SILVA, N. C. da; MAGALHÃES, P. C. Caracterização biométrica em caprinos do núcleo de conservação do ecotipo azul no Estado do Piauí. In: SIMPÓSIO INTERNACIONAL DE CONSERVAÇÃO DE RECURSOS GENÉTICOS, 2.; REUNIÃO DA REDE DE PEQUENOS RUMINANTES-PROSUL-CNPq, 1., 2005. Recife. Anais...Recife, 2005. 3 p. 1 CD-ROM. SINCORGE.Tipo: Artigo em Anais de Congresso / Nota Técnica |
Biblioteca(s): Embrapa Meio-Norte. |
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7. |  | ROCHA, R. R. C.; COSTA, A. P. R.; NASCIMENTO, H. T. S. do; CARDOSO, F. S.; SANTOS, P. A. C. dos; ALMEIDA, E. C. S. de; OLIVEIRA, L. de S. de. Frequência cardíaca da raças Marota e Saanen no período chuvoso em Teresina-PI. In: ENCONTRO DE INICIAÇÃO CIENTIFICA, 1.; PRÊMIO DE INICIAÇÃO CIENTIFICA DA FAPEPI, 1., 2005, [Teresina]. Anais...[Teresina]: FAPEPI, 2005. 1 CD-ROM.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Meio-Norte. |
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8. |  | SOUSA, A. C. de; BARBOSA FILHO, J. A. D.; GURGEL, J. F.; CARDOSO, F. I. F.; SANTOS, J. C. S. dos; SOUSA, A. M. de; ARAÚJO, M. G. M.; CORRÊA, W. C.; MARQUES, J. I.; LEITE, P. G.; PEREIRA, A. M.; OLIVEIRA JUNIOR, J. O. L. de; AZEVEDO, D. M. M. R.; HASSUM, I. C.; MACHADO, N. A. F. Analysis of convective heat transfer in dairy cattle via computational fluid dynamics. Journal of Animal Behaviour and Biometeorology, Online, Dec. 2024.Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
Biblioteca(s): Embrapa Meio-Norte. |
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Registros recuperados : 8 | |
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Nenhum registro encontrado para a expressão de busca informada. |
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