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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
11/12/2023 |
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Autoria: |
HENNESSY, D. R.; LACEY, E.; PRICHARD, R. K.; STEEL, J. W. |
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Título: |
Potentiation of the anthelmintic activity of oxfenbendazole by parbendazole. |
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Ano de publicação: |
1985 |
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Fonte/Imprenta: |
Journal Veterinary Pharmacology Therapic, v. 8, n. 3, p. 270-275, 1985. |
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DOI: |
https://doi.org/10.1111/j.1365-2885.1985.tb00956.x |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The ability of parbendazole (PBZ) to potentiate co-administered oxfendazole (OFZ) was investigated. Administration of a range (1.35–36.0 mg/kg) of doses of PBZ with 4.53 mg OKZ/kg demonstrated that signilicant potentiation occurred at 4.5 mg PBZ/kg. At 4.5 mg PBZ/kg, the area under the plasma OKZ concentration curve was about twice that obtained from oral administration of OFZ alone. When tested against benzimidazole-resistant Haemonchus contorolus and Trichostrongylus colubriformis, the mixture of 4.5 mg PBZ + 4.53 mg OKZ/kg was significantly more effective than 4.53 mg OFZ/kg alone, and PBZ alone showed no activity against these resistant nematodes. The demonstration of PBZ-OFZ potentiation has indicated a means of obtaining a more effective use of currently available anthelmintics in the treatment of helminthiasis. |
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Palavras-Chave: |
Anti-helminticos; Drug effects; Endoparasitos; Nematodeos; Resistance to anthelmintics. |
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Thesagro: |
Ovino; Parasitologia. |
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Thesaurus Nal: |
Anthelmintics; Benzimidazoles; Drug resistance; Parasitology; Sheep diseases. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 01764naa a2200313 a 4500
001 1522779
005 2023-12-11
008 1985 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1111/j.1365-2885.1985.tb00956.x$2DOI
100 1 $aHENNESSY, D. R.
245 $aPotentiation of the anthelmintic activity of oxfenbendazole by parbendazole.$h[electronic resource]
260 $c1985
520 $aAbstract: The ability of parbendazole (PBZ) to potentiate co-administered oxfendazole (OFZ) was investigated. Administration of a range (1.35–36.0 mg/kg) of doses of PBZ with 4.53 mg OKZ/kg demonstrated that signilicant potentiation occurred at 4.5 mg PBZ/kg. At 4.5 mg PBZ/kg, the area under the plasma OKZ concentration curve was about twice that obtained from oral administration of OFZ alone. When tested against benzimidazole-resistant Haemonchus contorolus and Trichostrongylus colubriformis, the mixture of 4.5 mg PBZ + 4.53 mg OKZ/kg was significantly more effective than 4.53 mg OFZ/kg alone, and PBZ alone showed no activity against these resistant nematodes. The demonstration of PBZ-OFZ potentiation has indicated a means of obtaining a more effective use of currently available anthelmintics in the treatment of helminthiasis.
650 $aAnthelmintics
650 $aBenzimidazoles
650 $aDrug resistance
650 $aParasitology
650 $aSheep diseases
650 $aOvino
650 $aParasitologia
653 $aAnti-helminticos
653 $aDrug effects
653 $aEndoparasitos
653 $aNematodeos
653 $aResistance to anthelmintics
700 1 $aLACEY, E.
700 1 $aPRICHARD, R. K.
700 1 $aSTEEL, J. W.
773 $tJournal Veterinary Pharmacology Therapic$gv. 8, n. 3, p. 270-275, 1985.
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| 1. |  | MANAWASINGHE, I. S.; HYDE, K. D.; WANASINGHE, D. N.; KARUNARATHNA, S. C.; MAHARACHCHIKUMBURA, S. S. N.; SAMARAKOON, M. C.; VOGLMAYR, H.; PANG, K.; CHIANG, M. W.; JONES, E. B. G.; SAXENA, R. K.; KUMAR, A.; RAJESHKUMAR, K. C.; SELBMANN, L.; COLEINE, C.; HU, Y.; AINSWORTH, A. M.; LIIMATAINEN, K.; NISKANEN, T.; RALAIVELOARISOA, A.; ARUMUGAM, E.; KEZO, K.; KALIYAPERUMAL, M.; GUNASEELAN, S.; DISSANAYAKE, A. J.; KHALID, A. N.; GAJANAYAKE, A. J.; FLAKUS, A.; ARMAND, A.; APTROOT, A.; RODRIGUES, A.; TSURYKAU, A.; LÓPEZ-VILLALBA, Á.; FARIAS, A. R. G. de; SÁNCHEZ, A.; GÓES-NETO, A.; GOTO, B. T.; SOUZA, C. A. F. de; CHUASEEHARONNACHAI, C.; LIN, C.; LI, C.; DENCHEV, C. M.; GUERRA-MATEO, D.; TENNAKOON, D. S.; WEI, D.; BEGEROW, D.; ALVES, E.; DRECHSLER-SANTOS, E. R.; SOUSA, E. S.; MEDEIROS, E. V. de; LANGER, E.; ZHANG, F.; SOUZA, F. A. de; MAGURNO, F.; BARRETO, G. G.; MORENO, G.; MANE, G.; ALVES-SILVA, G.; SILVA, G. A. da; XIA, G.; SHEN, H.; GUI, H.; SENANAYAKE, I. C.; LUANGSA-ARD, J. J.; LIU, J.; LIU, J.; MA, J.; LIN, J.; JR, J. E. A. B.; CANO-LIRA, J. F.; GENÉ, J.; HARIKRISHNAN, K.; LU, L.; SANTOS, L. A. dos; XU, L.; LACERDA, L. T.; GUSMÃO, L. F. P.; CÁCERES, M. E. S.; CÂMARA, M. P. S.; BARROS-BARRETO, M. B. B. de; CALABON, M. S.; KUKWA, M.; KEMLER, M.; MELO, M. P. de; GHOBAD-NEJHAD, M.; LUO, M.; DING, M.; DOILOM, M.; PHONEMANY, M.; USMAN, M.; THONGKLANG, N.; BOONYUEN, N.; ASHTEKAR, N.; KULARATHNAGE, N. D.; SRUTHI, O. P.; KWANTONG, P.; ANSIL, P. A.; KOOIJ, P. W.; ZHAO, Q.; ALFENAS, R. F.; OLIVEIRA, R. J. V. de; SINGH, R.; SILVA, R. M. F. da; AVCHAR, R.; MOREY, R.; SHARMA, R.; XU, R.; SILVEIRA, R. M. B. da; XU, R.; JAYAWARDENA, R. S.; NANU, S.; NUANKAEW, S.; TIBPROMMA, S.; BOONMIE, S.; SOMRITHIPOL, S.; VARGHESE, S.; MOREIRA, S. I.; RAJWAR, S.; HE, S.; KUMAR, T. K. A.; DENCHEV, T. T.; LUANGHARN, T.; OLIVEIRA, T. G. L. de; DU, T.; WEN, T.; DU, T.; WU, T.; SRI-INDRASUTDHI, V.; DOYLE, V. P.; BAULIN, V.; DONG, W.; LI, W.; LU, W.; TIAN, W.; VIEIRA, W. A. dos; BRACKEL, W. V.; YU, X.; ZHANG, X.; LIU, X.; PENG, X.; CHEN, Y.; YANG, Y.; GAO, Y.; XIONG, Y.; SHU, Y.; LU, Y.; SHEN, Y.; ZHOU, Y.; ZHANG, Y. X.; ZHANG, W.; LUO, Z.; MADUSHANI, M. A.; CHEEWANGKOON, R.; SONG, J. G.; XU, B. Fungal diversity notes 1818-1918: taxonomic and phylogenetic contributions on genera and species of fungi. Fungal Diversity, v. 130, p. 1-261, 2025.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
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