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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
29/06/2023 |
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Autoria: |
HSUEH, A. J. W.; JONES, P. B. C. |
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Título: |
Extrapituitary actions of gonadotropin-releasing hormone. |
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Ano de publicação: |
1981 |
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Fonte/Imprenta: |
Endocrinology Review, v. 2, n. 4, p. 437-461, 1981. |
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DOI: |
https://doi.org/10.1210/edrv-2-4-437 |
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Idioma: |
Inglês |
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Conteúdo: |
Harris (1) first proposed that the anterior pituitary gland is controlled by hypothalamic releasing factors. After the subsequent purification and sequencing of gonadotropin-releasing hormone (GnRH) (2, 3) and the synthesis of potent GnRH agonists and antagonists (4, 5), many laboratories have investigated the effects of these peptides on various reproductive functions. In both males and females, administration of GnRH or its potent agonists results in sustained increases in serum gonadotropins. In women, administration of GnRH causes preovulatory-like surges of gonadotropins (6, 7). In several animal species, a single injection of GnRH induces preovulatory- like surges of LH that trigger ovulation (8?11). Since pituitary gonadotropins are essential for normal gonadal functions and hypothalamic GnRH was believed to act solely on the pituitary gland, treatment with high doses of GnRH and its agonists had been predicted to be a potential means for enhancing fertility. Paradoxically, long term administration of pharmacological doses of GnRH or potent GnRH agonists was shown to decrease a variety of female and male reproductive functions (Table 1). |
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Palavras-Chave: |
Drug effects; Leuprolide. |
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Thesagro: |
Endocrinologia; Fisiologia; Gonadotrofina; Hormônio; Reprodução. |
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Thesaurus Nal: |
Corpus luteum hormones; Endocrinology; Gonadotropin-releasing hormone; Hormones; Pharmacology; Pituitary hormone-releasing hormones; Progesterone. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02060naa a2200313 a 4500
001 1521580
005 2023-06-29
008 1981 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1210/edrv-2-4-437$2DOI
100 1 $aHSUEH, A. J. W.
245 $aExtrapituitary actions of gonadotropin-releasing hormone.$h[electronic resource]
260 $c1981
520 $aHarris (1) first proposed that the anterior pituitary gland is controlled by hypothalamic releasing factors. After the subsequent purification and sequencing of gonadotropin-releasing hormone (GnRH) (2, 3) and the synthesis of potent GnRH agonists and antagonists (4, 5), many laboratories have investigated the effects of these peptides on various reproductive functions. In both males and females, administration of GnRH or its potent agonists results in sustained increases in serum gonadotropins. In women, administration of GnRH causes preovulatory-like surges of gonadotropins (6, 7). In several animal species, a single injection of GnRH induces preovulatory- like surges of LH that trigger ovulation (8?11). Since pituitary gonadotropins are essential for normal gonadal functions and hypothalamic GnRH was believed to act solely on the pituitary gland, treatment with high doses of GnRH and its agonists had been predicted to be a potential means for enhancing fertility. Paradoxically, long term administration of pharmacological doses of GnRH or potent GnRH agonists was shown to decrease a variety of female and male reproductive functions (Table 1).
650 $aCorpus luteum hormones
650 $aEndocrinology
650 $aGonadotropin-releasing hormone
650 $aHormones
650 $aPharmacology
650 $aPituitary hormone-releasing hormones
650 $aProgesterone
650 $aEndocrinologia
650 $aFisiologia
650 $aGonadotrofina
650 $aHormônio
650 $aReprodução
653 $aDrug effects
653 $aLeuprolide
700 1 $aJONES, P. B. C.
773 $tEndocrinology Review$gv. 2, n. 4, p. 437-461, 1981.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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