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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
02/01/2024 |
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Autoria: |
ADAMS, D. B.; DAVIES, H. I. |
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Título: |
Enhanced resistance to infection with haemonchus contortus in sheep treated with a corticosteroid. |
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Ano de publicação: |
1982 |
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Fonte/Imprenta: |
International Journal Parasitology, v. 12, n. 6, p. 523-529, Dec. 1982. |
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DOI: |
https://doi.org/10.1016/0020-7519(82)90047-9 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Adams D. B. and Davies H. I. 1982. Enhanced resistance to infection with Haemonchus contortus in sheep treated with a corticosteroid. International Journal for Parasitology12: 523–529. Fewer worms established from experimental infections with Haemonchus contortus in either immune or naive sheep or in sheep of undefined immune status given the corticosteroid, dexamethasone, around the time of challenge. In four experiments, the number of adult worms present in sheep treated with dexamethasone ranged from 32 to 36% of that in untreated animals. That the phenomenon did not stem from direct action of dexamethasone on the worms themselves was demonstrated by comparing continuous treatment with the drug from infection until patency with treatment given at infection and four days later. Sheep continuously treated with dexamethasone harboured similar numbers of worms as the infection controls whereas fewer parasites were found in sheep given dexamethasone around the time of infection. The results imply that active regulation of immunological unresponsiveness operates in sheep during infection with H. contortus and that disruption of immunoregulation by dexamethasone released protective responses thereby decreasing worm burdens. Because suppressor lymphocytes are implicated, cellular perturbations following treatment with dexamethasone were investigated. Dexamethasone did not cause marked lymphopenia. It, however, reduced blastogenic responses by lymphocytes to con A but not PHA. Comparison of responses to these mitogens in cells from blood and lymph demonstrates that con A and PHA-reactivity resides in identifiably different cell populations in sheep. MenosAbstract: Adams D. B. and Davies H. I. 1982. Enhanced resistance to infection with Haemonchus contortus in sheep treated with a corticosteroid. International Journal for Parasitology12: 523–529. Fewer worms established from experimental infections with Haemonchus contortus in either immune or naive sheep or in sheep of undefined immune status given the corticosteroid, dexamethasone, around the time of challenge. In four experiments, the number of adult worms present in sheep treated with dexamethasone ranged from 32 to 36% of that in untreated animals. That the phenomenon did not stem from direct action of dexamethasone on the worms themselves was demonstrated by comparing continuous treatment with the drug from infection until patency with treatment given at infection and four days later. Sheep continuously treated with dexamethasone harboured similar numbers of worms as the infection controls whereas fewer parasites were found in sheep given dexamethasone around the time of infection. The results imply that active regulation of immunological unresponsiveness operates in sheep during infection with H. contortus and that disruption of immunoregulation by dexamethasone released protective responses thereby decreasing worm burdens. Because suppressor lymphocytes are implicated, cellular perturbations following treatment with dexamethasone were investigated. Dexamethasone did not cause marked lymphopenia. It, however, reduced blastogenic responses by lymphocytes to con A but no... Mostrar Tudo |
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Palavras-Chave: |
Blastogenesis; Blood leukocytes; Corticosteroids; Immunological unresponsiveness; Nematodeos; Ovinos; Phytohaemagglutinin; Suppressor lymphocytes. |
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Thesagro: |
Haemonchus Contortus; Imunologia; Parasitologia. |
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Thesaurus Nal: |
Animal parasitic nematodes; Concanavalin A; Dexamethasone; Immune response; Sheep. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02713naa a2200337 a 4500
001 1521317
005 2024-01-02
008 1982 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/0020-7519(82)90047-9$2DOI
100 1 $aADAMS, D. B.
245 $aEnhanced resistance to infection with haemonchus contortus in sheep treated with a corticosteroid.$h[electronic resource]
260 $c1982
520 $aAbstract: Adams D. B. and Davies H. I. 1982. Enhanced resistance to infection with Haemonchus contortus in sheep treated with a corticosteroid. International Journal for Parasitology12: 523–529. Fewer worms established from experimental infections with Haemonchus contortus in either immune or naive sheep or in sheep of undefined immune status given the corticosteroid, dexamethasone, around the time of challenge. In four experiments, the number of adult worms present in sheep treated with dexamethasone ranged from 32 to 36% of that in untreated animals. That the phenomenon did not stem from direct action of dexamethasone on the worms themselves was demonstrated by comparing continuous treatment with the drug from infection until patency with treatment given at infection and four days later. Sheep continuously treated with dexamethasone harboured similar numbers of worms as the infection controls whereas fewer parasites were found in sheep given dexamethasone around the time of infection. The results imply that active regulation of immunological unresponsiveness operates in sheep during infection with H. contortus and that disruption of immunoregulation by dexamethasone released protective responses thereby decreasing worm burdens. Because suppressor lymphocytes are implicated, cellular perturbations following treatment with dexamethasone were investigated. Dexamethasone did not cause marked lymphopenia. It, however, reduced blastogenic responses by lymphocytes to con A but not PHA. Comparison of responses to these mitogens in cells from blood and lymph demonstrates that con A and PHA-reactivity resides in identifiably different cell populations in sheep.
650 $aAnimal parasitic nematodes
650 $aConcanavalin A
650 $aDexamethasone
650 $aImmune response
650 $aSheep
650 $aHaemonchus Contortus
650 $aImunologia
650 $aParasitologia
653 $aBlastogenesis
653 $aBlood leukocytes
653 $aCorticosteroids
653 $aImmunological unresponsiveness
653 $aNematodeos
653 $aOvinos
653 $aPhytohaemagglutinin
653 $aSuppressor lymphocytes
700 1 $aDAVIES, H. I.
773 $tInternational Journal Parasitology$gv. 12, n. 6, p. 523-529, Dec. 1982.
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| 1. |  | WRUCK, D. S. M.; SPERA, S. T.; FARIAS NETO, A. L. de; YORINORI, J. T.; RAMOS JUNIOR, E. U.; MENEGUCI, J. L. P.; LULU, J.; MAGALHAES, C. A. de S.; ZOLIN, C. A.; SILVA, A. F. da; ASSAD, E. D. Relatório da safra 2015/2016 no Estado do Mato Grosso. Sinop, MT: Embrapa, 2017. 25 p. (Embrapa Agrossilvipastoril. Documentos, 6)| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Agrossilvipastoril; Embrapa Milho e Sorgo; Embrapa Soja. |
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