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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Oriental. Para informações adicionais entre em contato com cpatu.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
20/03/2025 |
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Data da última atualização: |
20/03/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
NUNES, J. de A.; TEIXEIRA, L. L.; NASCIMENTO, W. M. O. do; LOPES, D. C. F.; SILVA, J. K. R. da; PINTO, L. C.; SANTOS, P. V. L.; FIGUEIREDO, P. F. B. |
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Afiliação: |
JENNIFER DE A. NUNES, UNIVERSIDADE DO ESTADO DO PARÁ; LEONAN L. TEIXEIRA, UNIVERSIDADE FEDERAL DO PARÁ; WALNICE MARIA O DO NASCIMENTO, CPATU; DIELLY C. F. LOPES, UNIVERSIDADE FEDERAL DO PARÁ; JOYCE KELLY R. DA SILVA, UNIVERSIDADE FEDERAL DO PARÁ; LAINE C. PINTO, UNIVERSIDADE FEDERAL DO PARÁ; PAULO VINICIUS L. SANTOS, UNIVERSIDADE DO ESTADO DO PARÁ; PABLO LUIS B. FIGUEIREDO, UNIVERSIDADE DO ESTADO DO PARÁ. |
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Título: |
Seasonal variation on chemical composition and in vitro cytotoxic and anti-inflammatory activities of Myrciaria dubia (Kunth) McVaugh essential oil from Amazon. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
Biochemical Systematics and Ecology, v. 121, 105001, Aug. 2025. |
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DOI: |
https://doi.org/10.1016/j.bse.2025.105001 |
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Idioma: |
Inglês |
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Conteúdo: |
Myrciaria dubia (Kunth) McVaugh is a fruit tree native to the Amazon, commonly known as camu-camu. This species has applications in traditional medicine, pharmaceuticals, and cosmetics due to its high content of phenolic compounds, such as anthocyanins and tannins in its fruits, which have antioxidant and anti-inflammatory properties. This work aims to evaluate the influence of seasonality on chemical composition, and in vitro cytotoxicity and anti-inflammatory activities of M. dubia essential oil. Botanical material was collected monthly, the leaf essential oils were extracted by hydrodistillation, and the fruits were subjected to simultaneous distillation-extraction. GC and GC-MS performed chemical analyses of the essential oils and volatile concentrates. The local climatic parameters insolation, temperature, relative humidity, and precipitation were monitored. The MTT assay was performed to evaluate cell viability. Subsequently, a nitrite standard curve was performed to determine the nitrite concentration in the samples. The oils were tested for cytotoxic activity against gastric ascites (AGP01), glioblastoma (AHOL), and lung cancer (A549) cell lines, as well as against non-malignant murine macrophages (RAW 264.7). The essential oil yield ranged from 0.4% (April/2024) to 0.9% (October/2023), with an annual average of 0.7 ± 0.1%. There were no significant differences in the yields of the dry and rainy periods. The leaf essential oils constituents were characterized by α-pinene (0.28–49.13%), (E)-caryophyllene (12.1–34.31%), caryophyllene oxide (4.03–17.08%), leptospermone (3.88–7.92%), and δ-cadinene (1.78–6.67%). The main compounds of fruit volatile concentrates were α-pinene (25.1–55.5%), α-terpineol (7.88–21.08%), limonene (6.43–16.79%), and (E)-caryophyllene (3.44–8.67%). The essential oils treatment of M. dubia seasonal study showed significant variations in the nitrite concentration, highlighting the oil's anti-inflammatory effect. The cytotoxic activity showed antiproliferative activity against cancer cell lines AGP01, AHOL, and A549, as well as non-malignant RAW 264.7. These results reinforce the value of M. dubia as a promising source for developing pharmaceutical ingredients, especially in combating inflammatory processes and cell therapy of tumor cell lines. MenosMyrciaria dubia (Kunth) McVaugh is a fruit tree native to the Amazon, commonly known as camu-camu. This species has applications in traditional medicine, pharmaceuticals, and cosmetics due to its high content of phenolic compounds, such as anthocyanins and tannins in its fruits, which have antioxidant and anti-inflammatory properties. This work aims to evaluate the influence of seasonality on chemical composition, and in vitro cytotoxicity and anti-inflammatory activities of M. dubia essential oil. Botanical material was collected monthly, the leaf essential oils were extracted by hydrodistillation, and the fruits were subjected to simultaneous distillation-extraction. GC and GC-MS performed chemical analyses of the essential oils and volatile concentrates. The local climatic parameters insolation, temperature, relative humidity, and precipitation were monitored. The MTT assay was performed to evaluate cell viability. Subsequently, a nitrite standard curve was performed to determine the nitrite concentration in the samples. The oils were tested for cytotoxic activity against gastric ascites (AGP01), glioblastoma (AHOL), and lung cancer (A549) cell lines, as well as against non-malignant murine macrophages (RAW 264.7). The essential oil yield ranged from 0.4% (April/2024) to 0.9% (October/2023), with an annual average of 0.7 ± 0.1%. There were no significant differences in the yields of the dry and rainy periods. The leaf essential oils constituents were characterized by α-pi... Mostrar Tudo |
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Thesagro: |
Camu Camu; Câncer; Composição Química; Myrciaria Dubia; Myrtaceae; Óleo Essencial; Variação Sazonal. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 03320naa a2200301 a 4500
001 2174104
005 2025-03-20
008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.bse.2025.105001$2DOI
100 1 $aNUNES, J. de A.
245 $aSeasonal variation on chemical composition and in vitro cytotoxic and anti-inflammatory activities of Myrciaria dubia (Kunth) McVaugh essential oil from Amazon.$h[electronic resource]
260 $c2025
520 $aMyrciaria dubia (Kunth) McVaugh is a fruit tree native to the Amazon, commonly known as camu-camu. This species has applications in traditional medicine, pharmaceuticals, and cosmetics due to its high content of phenolic compounds, such as anthocyanins and tannins in its fruits, which have antioxidant and anti-inflammatory properties. This work aims to evaluate the influence of seasonality on chemical composition, and in vitro cytotoxicity and anti-inflammatory activities of M. dubia essential oil. Botanical material was collected monthly, the leaf essential oils were extracted by hydrodistillation, and the fruits were subjected to simultaneous distillation-extraction. GC and GC-MS performed chemical analyses of the essential oils and volatile concentrates. The local climatic parameters insolation, temperature, relative humidity, and precipitation were monitored. The MTT assay was performed to evaluate cell viability. Subsequently, a nitrite standard curve was performed to determine the nitrite concentration in the samples. The oils were tested for cytotoxic activity against gastric ascites (AGP01), glioblastoma (AHOL), and lung cancer (A549) cell lines, as well as against non-malignant murine macrophages (RAW 264.7). The essential oil yield ranged from 0.4% (April/2024) to 0.9% (October/2023), with an annual average of 0.7 ± 0.1%. There were no significant differences in the yields of the dry and rainy periods. The leaf essential oils constituents were characterized by α-pinene (0.28–49.13%), (E)-caryophyllene (12.1–34.31%), caryophyllene oxide (4.03–17.08%), leptospermone (3.88–7.92%), and δ-cadinene (1.78–6.67%). The main compounds of fruit volatile concentrates were α-pinene (25.1–55.5%), α-terpineol (7.88–21.08%), limonene (6.43–16.79%), and (E)-caryophyllene (3.44–8.67%). The essential oils treatment of M. dubia seasonal study showed significant variations in the nitrite concentration, highlighting the oil's anti-inflammatory effect. The cytotoxic activity showed antiproliferative activity against cancer cell lines AGP01, AHOL, and A549, as well as non-malignant RAW 264.7. These results reinforce the value of M. dubia as a promising source for developing pharmaceutical ingredients, especially in combating inflammatory processes and cell therapy of tumor cell lines.
650 $aCamu Camu
650 $aCâncer
650 $aComposição Química
650 $aMyrciaria Dubia
650 $aMyrtaceae
650 $aÓleo Essencial
650 $aVariação Sazonal
700 1 $aTEIXEIRA, L. L.
700 1 $aNASCIMENTO, W. M. O. do
700 1 $aLOPES, D. C. F.
700 1 $aSILVA, J. K. R. da
700 1 $aPINTO, L. C.
700 1 $aSANTOS, P. V. L.
700 1 $aFIGUEIREDO, P. F. B.
773 $tBiochemical Systematics and Ecology$gv. 121, 105001, Aug. 2025.
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| 1. |  | OLIVEIRA, E. J. de; FUKUDA, W. M. G.; OLIVEIRA, S. A. S. de; RINGENBERG, R.; SILVA, M. R.; SOUZA, A. da S.; SILVA, A. L. L.; OLIVEIRA FILHO, M. dos S.; FARIA, M. L.; SILVA, R. de J. S. BRS Novo Horizonte - a new cassava variety for industrial use. Crop Breeding and Applied Biotechnology, v.20, n.2. e28882028, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
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