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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
24/09/2024 |
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Data da última atualização: |
29/11/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SANTOS, D. M. dos; MOON, J-I; KIM, D-S.; BASSOUS, N. J.; MARANGON, C. A.; CAMPANA-FILHO, S. P.; CORREA, D. S.; KANG, M-H.; KIM, W-J.; SHIN, S. R. |
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Afiliação: |
HARVARD MEDICAL SCHOOL; SEOUL NATIONAL UNIVERSITY; HARVARD MEDICAL SCHOOL; HARVARD MEDICAL SCHOOL; UNIVERSITY OF SÃO PAULO; UNIVERSITY OF SÃO PAULO; DANIEL SOUZA CORREA, CNPDIA; THE CATHOLIC UNIVERSITY OF KOREA; SEOUL NATIONAL UNIVERSITY; HARVARD MEDICAL SCHOOL. |
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Título: |
Hierarchical Chitin Nanocrystal-Based 3D Printed Dual-Layer Membranes Hydrogels: A Dual Drug Delivery Nano-Platform for Periodontal Tissue Regeneration. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
ACS Nano, v. 18, 2024. |
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Páginas: |
24182 - 24203 |
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DOI: |
https://doi.org/10.1021/acsnano.4c05558 |
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Idioma: |
Inglês |
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Conteúdo: |
ABSTRACT: Periodontitis, a prevalent chronic inflammatory disease caused by bacteria, poses a significant challenge to current treatments by merely slowing their progression. Herein, we propose an innovative solution in the form of hierarchical nanostructured 3D printed bilayer membranes that serve as dual-drug delivery nanoplatforms and provide scaffold function for the regeneration of periodontal tissue. Nanocomposite hydrogels were prepared by combining lipid nanoparticleloaded grape seed extract and simvastatin, as well as chitin nanocrystals, which were then 3D printed into a bilayer membrane that possesses antimicrobial properties and multiscale porosity for periodontal tissue regeneration. The constructs exhibited excellent mechanical properties by adding chitin nanocrystals and provided a sustained release of distinct drugs over 24 days. We demonstrated that the bilayer membranes are cytocompatible and have the ability to induce bone-forming markers in human mesenchymal stem cells, while showing potent antibacterial activity against pathogens associated with periodontitis. In vivo studies further confirmed the efficacy of bilayer membranes in enhancing alveolar bone regeneration and reducing inflammation in a periodontal defect model. This approach suggests promising avenues for the development of implantable constructs that not only combat infections, but also promote the regeneration of periodontal tissue, providing valuable insights into advanced periodontitis treatment strategies. MenosABSTRACT: Periodontitis, a prevalent chronic inflammatory disease caused by bacteria, poses a significant challenge to current treatments by merely slowing their progression. Herein, we propose an innovative solution in the form of hierarchical nanostructured 3D printed bilayer membranes that serve as dual-drug delivery nanoplatforms and provide scaffold function for the regeneration of periodontal tissue. Nanocomposite hydrogels were prepared by combining lipid nanoparticleloaded grape seed extract and simvastatin, as well as chitin nanocrystals, which were then 3D printed into a bilayer membrane that possesses antimicrobial properties and multiscale porosity for periodontal tissue regeneration. The constructs exhibited excellent mechanical properties by adding chitin nanocrystals and provided a sustained release of distinct drugs over 24 days. We demonstrated that the bilayer membranes are cytocompatible and have the ability to induce bone-forming markers in human mesenchymal stem cells, while showing potent antibacterial activity against pathogens associated with periodontitis. In vivo studies further confirmed the efficacy of bilayer membranes in enhancing alveolar bone regeneration and reducing inflammation in a periodontal defect model. This approach suggests promising avenues for the development of implantable constructs that not only combat infections, but also promote the regeneration of periodontal tissue, providing valuable insights into advanced periodontitis tre... Mostrar Tudo |
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Palavras-Chave: |
Antimicrobial property; Bone regeneration; Chitin nanocrystal; Nanocomposite hydrogel; Periodontal regeneration; Simvastatin. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02512naa a2200325 a 4500
001 2167544
005 2024-11-29
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1021/acsnano.4c05558$2DOI
100 1 $aSANTOS, D. M. dos
245 $aHierarchical Chitin Nanocrystal-Based 3D Printed Dual-Layer Membranes Hydrogels$bA Dual Drug Delivery Nano-Platform for Periodontal Tissue Regeneration.$h[electronic resource]
260 $c2024
300 $a24182 - 24203
520 $aABSTRACT: Periodontitis, a prevalent chronic inflammatory disease caused by bacteria, poses a significant challenge to current treatments by merely slowing their progression. Herein, we propose an innovative solution in the form of hierarchical nanostructured 3D printed bilayer membranes that serve as dual-drug delivery nanoplatforms and provide scaffold function for the regeneration of periodontal tissue. Nanocomposite hydrogels were prepared by combining lipid nanoparticleloaded grape seed extract and simvastatin, as well as chitin nanocrystals, which were then 3D printed into a bilayer membrane that possesses antimicrobial properties and multiscale porosity for periodontal tissue regeneration. The constructs exhibited excellent mechanical properties by adding chitin nanocrystals and provided a sustained release of distinct drugs over 24 days. We demonstrated that the bilayer membranes are cytocompatible and have the ability to induce bone-forming markers in human mesenchymal stem cells, while showing potent antibacterial activity against pathogens associated with periodontitis. In vivo studies further confirmed the efficacy of bilayer membranes in enhancing alveolar bone regeneration and reducing inflammation in a periodontal defect model. This approach suggests promising avenues for the development of implantable constructs that not only combat infections, but also promote the regeneration of periodontal tissue, providing valuable insights into advanced periodontitis treatment strategies.
653 $aAntimicrobial property
653 $aBone regeneration
653 $aChitin nanocrystal
653 $aNanocomposite hydrogel
653 $aPeriodontal regeneration
653 $aSimvastatin
700 1 $aMOON, J-I
700 1 $aKIM, D-S.
700 1 $aBASSOUS, N. J.
700 1 $aMARANGON, C. A.
700 1 $aCAMPANA-FILHO, S. P.
700 1 $aCORREA, D. S.
700 1 $aKANG, M-H.
700 1 $aKIM, W-J.
700 1 $aSHIN, S. R.
773 $tACS Nano$gv. 18, 2024.
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