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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
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Data corrente: |
23/05/2023 |
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Data da última atualização: |
23/05/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
NASCIMENTO, R. DE P. DO; RIZZATO, J. S.; POLEZI, G.; MOYA, A. M. T. M.; SILVA, M. F.; MACHADO, A. P. DA F.; FRANCHI JUNIOR, G. C.; BORGUINI, R. G.; SANTIAGO, M. C. P. de A.; PAIOTTI, A. P. R.; PEREIRA, J. A.; MARTINEZ, C. A. R.; MAROSTICA JUNIOR, M. R. |
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Afiliação: |
ROBERTO DE PAULA DO NASCIMENTO, UNICAMP; JULIA SOTO RIZZATO, UNICAMP; GABRIELE POLEZI, UNICAMP; AMANDA MARIA TOMAZINI MUNHOZ MOYA, UNICAMP; MILENA FERREIRA SILVA, UNIFESP; ANA PAULA DA FONSECA MACHADO, UNICAMP; GILBERTO CARLOS FRANCHI JUNIOR, UNICAMP; RENATA GALHARDO BORGUINI, CTAA; MANUELA CRISTINA P DE A SANTIAGO, CTAA; ANA PAULA RIBEIRO PAIOTTI, UNIFESP; JOSÉ AIRES PEREIRA, USF; CARLOS AUGUSTO REAL MARTINEZ, USF; MARIO ROBERTO MAROSTICA JUNIOR, UNICAMP. |
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Título: |
Freeze-dried jaboticaba (Myrciaria jaboticaba) peel powder, a rich source of anthocyanins and phenolic acids, mitigates inflammation-driven colorectal cancer in mice. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Food Bioscience, v, 53, e 102578, 2023. |
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DOI: |
https://doi.org/10.1016/j.fbio.2023.102578 |
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Idioma: |
Inglês |
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Conteúdo: |
This study aimed to characterize the peel of jaboticaba (Myrciaria jaboticaba (Vell.) O. Berg) by spectropho- tometry and chromatography, and investigate its effects on mice with inflammation-driven colorectal cancer (CRC). Freeze-dried jaboticaba peel (FDJP) showed a high antioxidant capacity in vitro, and to be mostly a source of cyanidin-3-O-glucoside, gallic acid, and ellagic acid. In the animal bioassay, FDJP added at 5% in the diet during 114 days completely abolished the formation of adenocarcinoma, which had an incidence of 75% in the non-treated group. Animals consuming FDJP showed low histology damage regarding inflammatory infiltrate, edema, and crypt distortion. FDJP significantly reduced the colonic levels of proinflammatory markers interleukin-1beta and cyclooxygenase-2, and demonstrated a probability to decrease the expressions of inducible nitric oxide synthase and nuclear factor kappa B. In summary, FDJP mitigated CRC, possibly by avoiding triggering inflammation. Such benefit may come from its rich content in anthocyanins and phenolic acids. |
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Palavras-Chave: |
Colitis Cyanidin-3-O-Glucoside; Flavonoid; Fruit. |
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Thesaurus Nal: |
Brazil; Carcinogenesis; Colitis; Food technology. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02215naa a2200361 a 4500
001 2153902
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008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.fbio.2023.102578$2DOI
100 1 $aNASCIMENTO, R. DE P. DO
245 $aFreeze-dried jaboticaba (Myrciaria jaboticaba) peel powder, a rich source of anthocyanins and phenolic acids, mitigates inflammation-driven colorectal cancer in mice.$h[electronic resource]
260 $c2023
520 $aThis study aimed to characterize the peel of jaboticaba (Myrciaria jaboticaba (Vell.) O. Berg) by spectropho- tometry and chromatography, and investigate its effects on mice with inflammation-driven colorectal cancer (CRC). Freeze-dried jaboticaba peel (FDJP) showed a high antioxidant capacity in vitro, and to be mostly a source of cyanidin-3-O-glucoside, gallic acid, and ellagic acid. In the animal bioassay, FDJP added at 5% in the diet during 114 days completely abolished the formation of adenocarcinoma, which had an incidence of 75% in the non-treated group. Animals consuming FDJP showed low histology damage regarding inflammatory infiltrate, edema, and crypt distortion. FDJP significantly reduced the colonic levels of proinflammatory markers interleukin-1beta and cyclooxygenase-2, and demonstrated a probability to decrease the expressions of inducible nitric oxide synthase and nuclear factor kappa B. In summary, FDJP mitigated CRC, possibly by avoiding triggering inflammation. Such benefit may come from its rich content in anthocyanins and phenolic acids.
650 $aBrazil
650 $aCarcinogenesis
650 $aColitis
650 $aFood technology
653 $aColitis Cyanidin-3-O-Glucoside
653 $aFlavonoid
653 $aFruit
700 1 $aRIZZATO, J. S.
700 1 $aPOLEZI, G.
700 1 $aMOYA, A. M. T. M.
700 1 $aSILVA, M. F.
700 1 $aMACHADO, A. P. DA F.
700 1 $aFRANCHI JUNIOR, G. C.
700 1 $aBORGUINI, R. G.
700 1 $aSANTIAGO, M. C. P. de A.
700 1 $aPAIOTTI, A. P. R.
700 1 $aPEREIRA, J. A.
700 1 $aMARTINEZ, C. A. R.
700 1 $aMAROSTICA JUNIOR, M. R.
773 $tFood Bioscience, v, 53, e 102578, 2023.
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Registro original: |
Embrapa Agroindústria de Alimentos (CTAA) |
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