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 | Acesso ao texto completo restrito à biblioteca da Embrapa Semiárido. Para informações adicionais entre em contato com cpatsa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Semiárido. |
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Data corrente: |
09/09/2022 |
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Data da última atualização: |
16/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LOUBET FILHO, P. S.; BASEGGIO, A. M.; VUOLO, M. R.; REGUENGO, L. M.; BIASOTO, A. C. T.; CORREA, L. C.; BOGUSZ JUNIOR, s.; CAGNON, V. H. A.; CAZARIN, C. B. B.; MARÓSTICA JÚNIOR, M. R. |
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Afiliação: |
PAULO SÉRGIO LOUBET FILHO, UNICAMP; ANDRESSA MARA BASEGGIO, UNICAMP; MILENA MORANDI VUOLO, UNICAMP; LÍVIA MATEUS REGUENGO, UNICAMP; ALINE TELLES BIASOTO MARQUES, CPATSA; LUIZ CLAUDIO CORREA, CPATSA; STANISLAU BOGUSZ JUNIOR, USP, São Carlos; VALÉRIA HELENA ALVES CAGNON, UNICAMP; CINTHIA BAÚ BETIM CAZARIN, UNICAMP; MÁRIO ROBERTO MARÓSTICA JÚNIOR, UNICAMP. |
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Título: |
Gut microbiota modulation by jabuticaba peel and its effect on glucose metabolism via inflammatory signaling. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Current Research in Food Science, v. 5, p. 382-391, 2022. |
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DOI: |
https://doi.org/10.1016/j.crfs.2022.02.001 |
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Idioma: |
Inglês |
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Conteúdo: |
Jabuticaba is a Brazilian berry known for its therapeutic potential against cancer, obesity, insulin resistance (IR), and others. It is a natural source of bioactive compounds, leading to better glucose metabolism, and attenuating obesity and IR through the reduction of pro-inflammatory status. The present study aimed to observe the prebiotic effect of freeze-dried jabuticaba peel (J) consumption on gut bacteria profile and describe its effects on IR derived from the lipopolysaccharides/Toll-like receptor-4 inflammatory pathway. Jabuticaba peel was chemically characterized, and its bioactive compounds were quantified. Twenty-four C57BL/6 mice were feed with a control diet (n = 6), control diet + J (n = 6), high-fat diet (HF) (n = 6), and HF + J (n = 6) for thirteen weeks. Gut bacteriota (16s RNA sequencing), glucose metabolism (fasting glucose and insulin, OGTT, ITT, HOMA-IR, and β, QUICKI), and inflammatory status (serum lipopolysaccharide, and protein expression) were assessed. The main bioactive compounds found in J were dietary fiber, and anthocyanins, and its consumption along with a healthy diet reduced the abundance of Firmicutes and Actinobacteriota phyla (p < 0.01), increased the Muribaculaceae and Lachnospiraceae families, and Faecalicatena genus (p < 0.05). The correlation test indicates a negative correlation between the Muribaculaceae and glucose metabolism. Jabuticaba peel is a nutritive source of bioactive compounds with prebiotic effects. |
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Palavras-Chave: |
Bactérias intestinais; Baga; Compostos bioativos; Consumo de casca de jabuticaba; Disbiose; Microbiota intestinal; Prebióticos; Resistência a insulina. |
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Thesagro: |
Jabuticaba; Obesidade. |
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Thesaurus Nal: |
Bioactive compounds; Insulin resistance; Obesity; Prebiotics. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02720naa a2200409 a 4500
001 2146303
005 2023-01-16
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.crfs.2022.02.001$2DOI
100 1 $aLOUBET FILHO, P. S.
245 $aGut microbiota modulation by jabuticaba peel and its effect on glucose metabolism via inflammatory signaling.$h[electronic resource]
260 $c2022
520 $aJabuticaba is a Brazilian berry known for its therapeutic potential against cancer, obesity, insulin resistance (IR), and others. It is a natural source of bioactive compounds, leading to better glucose metabolism, and attenuating obesity and IR through the reduction of pro-inflammatory status. The present study aimed to observe the prebiotic effect of freeze-dried jabuticaba peel (J) consumption on gut bacteria profile and describe its effects on IR derived from the lipopolysaccharides/Toll-like receptor-4 inflammatory pathway. Jabuticaba peel was chemically characterized, and its bioactive compounds were quantified. Twenty-four C57BL/6 mice were feed with a control diet (n = 6), control diet + J (n = 6), high-fat diet (HF) (n = 6), and HF + J (n = 6) for thirteen weeks. Gut bacteriota (16s RNA sequencing), glucose metabolism (fasting glucose and insulin, OGTT, ITT, HOMA-IR, and β, QUICKI), and inflammatory status (serum lipopolysaccharide, and protein expression) were assessed. The main bioactive compounds found in J were dietary fiber, and anthocyanins, and its consumption along with a healthy diet reduced the abundance of Firmicutes and Actinobacteriota phyla (p < 0.01), increased the Muribaculaceae and Lachnospiraceae families, and Faecalicatena genus (p < 0.05). The correlation test indicates a negative correlation between the Muribaculaceae and glucose metabolism. Jabuticaba peel is a nutritive source of bioactive compounds with prebiotic effects.
650 $aBioactive compounds
650 $aInsulin resistance
650 $aObesity
650 $aPrebiotics
650 $aJabuticaba
650 $aObesidade
653 $aBactérias intestinais
653 $aBaga
653 $aCompostos bioativos
653 $aConsumo de casca de jabuticaba
653 $aDisbiose
653 $aMicrobiota intestinal
653 $aPrebióticos
653 $aResistência a insulina
700 1 $aBASEGGIO, A. M.
700 1 $aVUOLO, M. R.
700 1 $aREGUENGO, L. M.
700 1 $aBIASOTO, A. C. T.
700 1 $aCORREA, L. C.
700 1 $aBOGUSZ JUNIOR, s.
700 1 $aCAGNON, V. H. A.
700 1 $aCAZARIN, C. B. B.
700 1 $aMARÓSTICA JÚNIOR, M. R.
773 $tCurrent Research in Food Science$gv. 5, p. 382-391, 2022.
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Registro original: |
Embrapa Semiárido (CPATSA) |
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| Registros recuperados : 3 | |
| 2. |  | SEO, J.; OSORIO, J. S.; SCHMITT, E.; CORRÊA, M. N.; BERTONI, G.; TREVISI, E.; LOOR, J. J. Hepatic purinergic signaling gene network expression and its relationship with inflammation and oxidative stress biomarkers in blood from peripartal dairy cattle. Journal of Dairy Science, Chanpaign, v. 97, n. 2, p. 861-873, 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Rondônia. |
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| 3. | | JACOMETO, C. B.; SCHMITT, E.; PFEIFER, L. F. M.; SCHNEIDER, A.; BADO, F.; ROSA, F. T. da; HALFEN, S.; DEL PINO, F. A. B.; LOOR, J. J.; CORRÊA, M. N.; DIONELLO, N. J. L. Linoleic and a-linolenic fatty acid consumption over three generations exert cumulative regulation of hepatic expression of genes related to lipid metabolism. Genes & Nutrition, v. 9, n. 38, art. 423, 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Rondônia. |
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| Registros recuperados : 3 | |
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