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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
11/08/2021 |
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Data da última atualização: |
11/08/2021 |
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Tipo da produção científica: |
Nota Técnica/Nota Científica |
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Autoria: |
FONSECA, M. D. M.; MAIA, J. M. S.; VARAGO, F. C.; GERN, J. C.; CARVALHO, W. A.; SILVA, S. R.; MOSQUEIRA, V. C. F.; BRANDAO, H. de M.; GUIMARÃES, A. S. |
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Afiliação: |
Universidade Federal de Lavras; Universidade Federal de Lavras; JULIANA CARINE GERN, CNPGL; WANESSA ARAUJO CARVALHO, CNPGL; Universidade Federal de Ouro Preto; Universidade Federal de Ouro Preto; HUMBERTO DE MELLO BRANDAO, CNPGL; ALESSANDRO DE SA GUIMARAES, CNPGL. |
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Título: |
Cloxacillin nanostructured formulation for the treatment of bovine keratoconjunctivitis. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Veterinary and Animal Science, v. 9, 100089, 2020. |
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DOI: |
https://doi.org/10.1016/j.vas.2020.100089 |
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Idioma: |
Inglês |
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Notas: |
Short communication. |
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Conteúdo: |
Infectious bovine keratoconjunctivitis (IBK) is a widespread, contagious ocular disease that affects cattle, especially dairy breeds. The disease is caused by Gram-negative bacteria mainly Moraxella bovis, and its treatment consists of parenteral or topic antibiotic therapy. The topic treatment approach is used more commonly in lactating cows, to avoid milk disposal. However, treatment failures are common, because the antibiotic is removed during lacrimation. This study aimed to evaluate the susceptibility of commercial cloxacillin and evaluate the efficacy of nanostructured cloxacillin in clinical cases of IBK by Moraxella. The minimum inhibitory concentration (MIC) of nanoparticle cloxacillin nanocoated, the nanoparticle without the antibiotic and the commercial cloxacillin were determined in vitro with field samples of Moraxella ovis (5) and Moraxella bovis (5). The efficiency of nanoparticles was tested in three cows naturally infected that were treated with 1.0 mL (with 0.32 mg of nanostructured cloxacillin) for the ocular route. Moraxella bovis was isolated and identified by biochemical and molecular methods before the treatment. The animals were treated every 12 h for six days. The cure was considered by the absence of clinical symptoms and bacteria after treatment. The mucoadhesive nanoparticlebased formulation promoted clinical cure with a low number of doses of antibiotics, probably due to the maintenance of the MIC in the ocular mucosa for longer due to the mucoadhesive characteristics of the nanoparticle. The results indicate that the use of nanocoated cloxacillin is possible to control infectious bovine keratoconjunctivitis. MenosInfectious bovine keratoconjunctivitis (IBK) is a widespread, contagious ocular disease that affects cattle, especially dairy breeds. The disease is caused by Gram-negative bacteria mainly Moraxella bovis, and its treatment consists of parenteral or topic antibiotic therapy. The topic treatment approach is used more commonly in lactating cows, to avoid milk disposal. However, treatment failures are common, because the antibiotic is removed during lacrimation. This study aimed to evaluate the susceptibility of commercial cloxacillin and evaluate the efficacy of nanostructured cloxacillin in clinical cases of IBK by Moraxella. The minimum inhibitory concentration (MIC) of nanoparticle cloxacillin nanocoated, the nanoparticle without the antibiotic and the commercial cloxacillin were determined in vitro with field samples of Moraxella ovis (5) and Moraxella bovis (5). The efficiency of nanoparticles was tested in three cows naturally infected that were treated with 1.0 mL (with 0.32 mg of nanostructured cloxacillin) for the ocular route. Moraxella bovis was isolated and identified by biochemical and molecular methods before the treatment. The animals were treated every 12 h for six days. The cure was considered by the absence of clinical symptoms and bacteria after treatment. The mucoadhesive nanoparticlebased formulation promoted clinical cure with a low number of doses of antibiotics, probably due to the maintenance of the MIC in the ocular mucosa for longer due to the mucoad... Mostrar Tudo |
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Palavras-Chave: |
Ceratoconjuntivite; Cloxacilina; Nanoestrutura; Nanopartícula mucoadesiva. |
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Thesagro: |
Bovino; Doença Animal; Moraxella Bovis. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02630naa a2200325 a 4500
001 2133453
005 2021-08-11
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.vas.2020.100089$2DOI
100 1 $aFONSECA, M. D. M.
245 $aCloxacillin nanostructured formulation for the treatment of bovine keratoconjunctivitis.$h[electronic resource]
260 $c2020
500 $aShort communication.
520 $aInfectious bovine keratoconjunctivitis (IBK) is a widespread, contagious ocular disease that affects cattle, especially dairy breeds. The disease is caused by Gram-negative bacteria mainly Moraxella bovis, and its treatment consists of parenteral or topic antibiotic therapy. The topic treatment approach is used more commonly in lactating cows, to avoid milk disposal. However, treatment failures are common, because the antibiotic is removed during lacrimation. This study aimed to evaluate the susceptibility of commercial cloxacillin and evaluate the efficacy of nanostructured cloxacillin in clinical cases of IBK by Moraxella. The minimum inhibitory concentration (MIC) of nanoparticle cloxacillin nanocoated, the nanoparticle without the antibiotic and the commercial cloxacillin were determined in vitro with field samples of Moraxella ovis (5) and Moraxella bovis (5). The efficiency of nanoparticles was tested in three cows naturally infected that were treated with 1.0 mL (with 0.32 mg of nanostructured cloxacillin) for the ocular route. Moraxella bovis was isolated and identified by biochemical and molecular methods before the treatment. The animals were treated every 12 h for six days. The cure was considered by the absence of clinical symptoms and bacteria after treatment. The mucoadhesive nanoparticlebased formulation promoted clinical cure with a low number of doses of antibiotics, probably due to the maintenance of the MIC in the ocular mucosa for longer due to the mucoadhesive characteristics of the nanoparticle. The results indicate that the use of nanocoated cloxacillin is possible to control infectious bovine keratoconjunctivitis.
650 $aBovino
650 $aDoença Animal
650 $aMoraxella Bovis
653 $aCeratoconjuntivite
653 $aCloxacilina
653 $aNanoestrutura
653 $aNanopartícula mucoadesiva
700 1 $aMAIA, J. M. S.
700 1 $aVARAGO, F. C.
700 1 $aGERN, J. C.
700 1 $aCARVALHO, W. A.
700 1 $aSILVA, S. R.
700 1 $aMOSQUEIRA, V. C. F.
700 1 $aBRANDAO, H. de M.
700 1 $aGUIMARÃES, A. S.
773 $tVeterinary and Animal Science$gv. 9, 100089, 2020.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 11 | |
| 1. |  | COSTA, A. P. R.; ANDRADE, D. R. de; VIDAL JUNIOR, M. V.; SOUZA, G. Indicadores quantitativos da biologia reprodutiva de fêmeas de piau-vermelho no Rio Paraíba do Sul. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 40, n. 8, p. 789-795, ago. 2005 Título em inglês: Indicators on the reproductive biology of female red-piau in Paraíba do Sul River.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 3. | | AZEVEDO, R. V. de; FOSSE FILHO, J. C.; CARDOSO, L. D.; VIDAL JÚNIOR, M. V.; ANDRADE, D. R. de. Suplementação com prebiótico, probiótico e simbiótico para juvenis de tambaqui e duas densidades de estocagem. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 51, n. 1, p. 9-16, jan. 2016. Título em inglês: Prebiotic, probiotic and synbiotic supplementation in diets for juvenile tambaquis at two stocking densities.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 4. | | ALMAGRO, W. S.; DEUS-DE-OLIVEIRA, N.; REZENDE, T.; MANHÃES, J. V. de A.; MACHADO, O. L. T.; VIDAL JUNIOR, M. V.; ANDRADE, D. R. de. Avaliação do uso de torta de mamona (RICINUS COMMUNIS L.) desativada na ração para alimentação do ASTYANAX BIMACULATUS (LAMBARI) cultivado em sistema semi-intensivo. CONGRESSO BRASILEIRO DE MAMONA, 5.; SIMPÓSIO INTERNACIONAL DE OLEAGINOSAS ENERGÉTICAS, 2.; FÓRUM CAPIXABA DE PINHÃO-MANSO, 1., 2012, Guarapari. Desafios e Oportunidades: anais. Campina Grande: Embrapa Algodão, 2012. p. 396| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Algodão. |
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| 5. | | RADAEL, M. C.; FOSSE, P. J.; SILVA, R. M. da; FOSSE FILHO, J. C.; ANDRADE, D. R. de; VIDAL JUNIOR, M. V. Descrição morfológica dos ovários do peixe melanotaenia boesemani em atividade reprodutiva. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 9, p. 893-900, set. 2016.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 6. | | MENDONÇA, P. P.; VIDAL JUNIOR, M. V.; POLESE, M. F.; SANTOS, M. V. B. dos; REZENDE, F. P.; ANDRADE, D. R. de. Morphometrical development of tambaqui (Colossoma macropomum, Cuvier, 1818) under different photoperiods. Revista Brasileira de Zootecnia, Viçosa, MG, v. 41, n. 6, p. 1337-1341, jun. 2012.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Pesca e Aquicultura. |
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| 7. | | MUZITANO, I. S.; NEVES, C. A.; RADAEL, M. C.; REZENDE, F. P.; MENDONÇA, P. P.; SANTOS, M. V. B. dos; ANDRADE, D. R. de; VIDAL JUNIOR, M. V. Suplementação de vitamina C na estruturação do tecido conjuntivo de melanotênia-maçã. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 34, n. 8, p. 780-784, ago. 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Pesca e Aquicultura. |
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| 8. | | ANDRADE, D. R. de F.; REZENDE, A. S. C.; SANTOS, S. A.; NOGUEIRA, M. F.; SANTIAGO, J. M.; LAGE, J.; MELO, M. M.; REIS, J. K. P.; TRIGO, P. Equine infectious anemia affects the athletic performance of equines from the Brazilian Pantanal region. Pesquisa Agropecuária Brasileira, Brasília,DF, v. 53, n. 10, p. 1184-1188, 2018.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Pantanal. |
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| 9. | | ANDRADE, D. R. de F.; REZENDE, A. S. C.; SANTOS, S. A.; NOGUEIRA, M. F.; SANTIAGO, J. M.; LAGE, J.; MELO, M. M.; REIS, J. K. P.; TRIG, P. Equine infectious anemia affects the athletic performance of equines from the Brazilian Pantanal region. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 53, n. 10, p. 1184-1188, Oct. 2018. Notas Científicas.
Título em português: Anemia infecciosa equina afeta o desempenho atlético de equinos da região do Pantanal brasileiro.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 10. | | SOUZA, G. da S. e; GOMES, E. G.; SANTOS, S. A.; REZENDE, A. S. C. de; ANDRADE, D. R. de F.; NOGUEIRA, M. F.; TRIGO, P.; ABREU, U. G. P. de. Factors affecting the performance of Pantaneiro horses. Revista Brasileira de Zootecnia, Viçosa, v. 47, Epub Mar 2018| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Pantanal; Embrapa Unidades Centrais. |
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| 11. | | GOMES, G. M. F.; CÂNDIDO, M. J. D.; LOPES, M. N.; MARANHÃO, T. D.; ANDRADE, D. R. de; COSTA, J. F. M.; SILVEIRA, W. M.; NEIVA, J. N. M. Chemical composition of cactus pear cladodes under different fertilization and harvesting managements. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 53, n. 2, p. 221-228, Fev. 2018. Título em português: Composição química de cladódios de palma forrageira sob diferentes manejos de adubação e colheita.| Biblioteca(s): Embrapa Unidades Centrais. |
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| Registros recuperados : 11 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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