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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria de Alimentos. Para informações adicionais entre em contato com ctaa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
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Data corrente: |
16/12/2020 |
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Data da última atualização: |
05/02/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ROMUALDO, G. R.; SOUZA, I. P. de; SOUZA, L. V. de; PRATA, G. B.; FRAGA-SILVA, T. F. de; SARTORI, A.; BORGUINI, R. G.; SANTIAGO, M. C. P. de A.; FERNANDES, A. A. H.; COGLIATI, B.; BARBOSAN, L. F. |
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Afiliação: |
Guilherme Ribeiro Romualdo, UNESP; Isadora Penedo de Souza, UNESP; Lucas Vilhegas de Souza, UNESP; Gabriel Bacil Prata, UNESP; Thais Fernanda de Campos Fraga-Silva, UNESP; Alexandrina Sartori, UNESP; RENATA GALHARDO BORGUINI, CTAA; MANUELA CRISTINA P DE A SANTIAGO, CTAA; Ana Angélica Henrique Fernandes, UNESP; Bruno Cogliati, USP; Luís Fernando Barbisan, UNESP. |
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Título: |
Beneficial effects of anthocyanin-rich peels of Myrtaceae fruits on chemically-induced liver fibrosis and carcinogenesis in mice. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Food Research International, v. 139, 109964, 2021. p. 1-11. |
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DOI: |
https://doi.org/10.1016/j.foodres.2020.109964 |
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Idioma: |
Inglês |
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Conteúdo: |
Hepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-?). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increased total glutathione levels. S. cumini peel feeding reduced hepatic collagen, lipid peroxidation, and TNF-? levels while increased catalase activity. Although S. malaccense peel powder, which displayed the lowest anthocyanin levels, decreased oxidative stress, and cytokine levels, no effects were observed on liver fibrosis or preneoplastic lesion outcomes. Findings indicate a protective effect of anthocyanin-rich M. jaboticaba and S. cumini peel powder feeding on preneoplastic lesion development and fibrosis, respectively. Results indicate that differential biological responses may be attributed to distinct anthocyanin profiles and levels, assigning a functional/market value to the underutilized peel fraction. MenosHepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-?). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increas... Mostrar Tudo |
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Thesaurus Nal: |
Anthocyanins; Fruit peels; Myrciaria; Syzygium cumini. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 03166naa a2200301 a 4500
001 2128263
005 2021-02-05
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.foodres.2020.109964$2DOI
100 1 $aROMUALDO, G. R.
245 $aBeneficial effects of anthocyanin-rich peels of Myrtaceae fruits on chemically-induced liver fibrosis and carcinogenesis in mice.$h[electronic resource]
260 $c2021
520 $aHepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-?). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increased total glutathione levels. S. cumini peel feeding reduced hepatic collagen, lipid peroxidation, and TNF-? levels while increased catalase activity. Although S. malaccense peel powder, which displayed the lowest anthocyanin levels, decreased oxidative stress, and cytokine levels, no effects were observed on liver fibrosis or preneoplastic lesion outcomes. Findings indicate a protective effect of anthocyanin-rich M. jaboticaba and S. cumini peel powder feeding on preneoplastic lesion development and fibrosis, respectively. Results indicate that differential biological responses may be attributed to distinct anthocyanin profiles and levels, assigning a functional/market value to the underutilized peel fraction.
650 $aAnthocyanins
650 $aFruit peels
650 $aMyrciaria
650 $aSyzygium cumini
700 1 $aSOUZA, I. P. de
700 1 $aSOUZA, L. V. de
700 1 $aPRATA, G. B.
700 1 $aFRAGA-SILVA, T. F. de
700 1 $aSARTORI, A.
700 1 $aBORGUINI, R. G.
700 1 $aSANTIAGO, M. C. P. de A.
700 1 $aFERNANDES, A. A. H.
700 1 $aCOGLIATI, B.
700 1 $aBARBOSAN, L. F.
773 $tFood Research International$gv. 139, 109964, 2021. p. 1-11.
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Registro original: |
Embrapa Agroindústria de Alimentos (CTAA) |
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Biblioteca |
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Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
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Registro Completo
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Biblioteca(s): |
Embrapa Tabuleiros Costeiros. |
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Data corrente: |
17/05/2011 |
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Data da última atualização: |
19/05/2011 |
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Autoria: |
CARVALHO, H. W. L. de; CARDOSO, M. J.; GAMA, E. E. G. e; GUIMARAES, P. E. O.; PACHECO, C. A. P.; SILVA, A. A. G. da; TABOSA, J. N.; LIRA, M. A.; SOUSA, E. M. de; CARVALHO, E. C. L. de; SAMPAIO, G. V.; SOUZA, I. V. B. de; DOURADO, V. V.; CAVALCANTE, M. H. B.; NASCIMENTO, M. M. A. do; BRITO, A. R. de M. B.; TAVARES FILHO, J. J.; TAVARES, J. A. |
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Afiliação: |
HELIO WILSON LEMOS DE CARVALHO, CPATC; MILTON JOSE CARDOSO, CPAMN; ELTO EUGENIO GOMES E GAMA; PAULO EVARISTO OLIVEIRA GUIMARAES; CLESO ANTONIO PATTO PACHECO, CNPMS; ANA ALEXANDRINA GAMA DA SILVA, CPATC; JOSE NILDO TABOSA; MARCELO ABDON LIRA; EVANILDES MENEZES DE SOUSA; BENEDITO CARLOS LEMOS DE CARVALHO; GIDERVAL VIEIRA SAMPAIO; IVAN VILAS BOAS DE SOUZA; VALFREDO VILELA DOURADO; MANOEL HENRIQUE BONFIM CAVALCANTE; MARTA MARIA AMANCIO DO NASCIMENTO; ANA RITA DE MORAIS DE BRANDAO BRITO; JOSE JORGE TAVARES FILHO; JORGE ALVES TAVARES. |
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Título: |
Recomendação de variedades de milho para o Nordeste brasileiro. |
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Ano de publicação: |
2005 |
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Fonte/Imprenta: |
Aracaju: Embrapa Tabuleiros Costeiros, 2005. |
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Páginas: |
6 p. |
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Série: |
(Embrapa Tabuleiros Costeiros. Comunicado Técnico, 45). |
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Idioma: |
Português |
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Palavras-Chave: |
Cron; Cultivar. |
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Thesagro: |
Milho. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/34810/1/cot-45.pdf
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Marc: |
LEADER 01064nam a2200361 a 4500
001 1888766
005 2011-05-19
008 2005 bl uuuu u0uu1 u #d
100 1 $aCARVALHO, H. W. L. de
245 $aRecomendação de variedades de milho para o Nordeste brasileiro.$h[electronic resource]
260 $aAracaju: Embrapa Tabuleiros Costeiros$c2005
300 $a6 p.
490 $a(Embrapa Tabuleiros Costeiros. Comunicado Técnico, 45).
650 $aMilho
653 $aCron
653 $aCultivar
700 1 $aCARDOSO, M. J.
700 1 $aGAMA, E. E. G. e
700 1 $aGUIMARAES, P. E. O.
700 1 $aPACHECO, C. A. P.
700 1 $aSILVA, A. A. G. da
700 1 $aTABOSA, J. N.
700 1 $aLIRA, M. A.
700 1 $aSOUSA, E. M. de
700 1 $aCARVALHO, E. C. L. de
700 1 $aSAMPAIO, G. V.
700 1 $aSOUZA, I. V. B. de
700 1 $aDOURADO, V. V.
700 1 $aCAVALCANTE, M. H. B.
700 1 $aNASCIMENTO, M. M. A. do
700 1 $aBRITO, A. R. de M. B.
700 1 $aTAVARES FILHO, J. J.
700 1 $aTAVARES, J. A.
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Embrapa Tabuleiros Costeiros (CPATC) |
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