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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
06/07/2017 |
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Data da última atualização: |
27/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ORTEGA, M. S.; WOHLGEMUTH, S.; TRIBULO, P.; SIQUEIRA, L. G. B.; NULL, D. J.; COLE, J. B.; SILVA, M. V. G. B.; HANSEN, P. J. |
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Afiliação: |
M. Sofia Ortega, University of Florida; Stephanie Wohlgemuth, University of Florida; Paula Tribulo, University of Florida; LUIZ GUSTAVO BRUNO SIQUEIRA, CNPGL; Daniel J. Null, United States Department of Agriculture; John B. Cole, United States Department of Agriculture; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; Peter J. Hansen, University of Florida. |
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Título: |
A single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Biology of Reproduction, v. 96, n. 3, p. 652-663, 2017. |
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Idioma: |
Inglês |
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Conteúdo: |
A single missense mutation at position 159 of coenzyme Q9 (COQ9) (G→A; rs109301586) has been associated with genetic variation in fertility in Holstein cattle, with the A allele associated with higher fertility. COQ9 is involved in the synthesis of coenzyme COQ10, a component of the electron transport system of the mitochondria. Here we tested whether reproductive phenotype is associated with the mutation and evaluated functional consequences for cellular oxygen metabolism, body weight changes, and ovarian function. The mutation in COQ9 modifies predicted tertiary protein structure and affected mitochondrial respiration of peripheral blood mononuclear cells. The A allele was associated with low resting oxygen consumption and high electron transport system capacity. Phenotypic measurements for fertility were evaluated for up to five lactations in a population of 2273 Holstein cows. There were additive effects of the mutation (P < 0.05) in favor of the A allele for pregnancy rate, interval from calving to conception, and services per conception. There was no association of genotype with milk production or body weight changes postpartum. The mutation in COQ9 affected ovarian function; the A allele was associated with increased mitochondrial DNA copy number in oocytes, and there were overdominance effects for COQ9 expression in oocytes, follicle number, and antimullerian hormone concentrations. Overall, results show how a gene involved in mitochondrial function is associated with overall fertility, possibly in part by affecting oocyte quality. MenosA single missense mutation at position 159 of coenzyme Q9 (COQ9) (G→A; rs109301586) has been associated with genetic variation in fertility in Holstein cattle, with the A allele associated with higher fertility. COQ9 is involved in the synthesis of coenzyme COQ10, a component of the electron transport system of the mitochondria. Here we tested whether reproductive phenotype is associated with the mutation and evaluated functional consequences for cellular oxygen metabolism, body weight changes, and ovarian function. The mutation in COQ9 modifies predicted tertiary protein structure and affected mitochondrial respiration of peripheral blood mononuclear cells. The A allele was associated with low resting oxygen consumption and high electron transport system capacity. Phenotypic measurements for fertility were evaluated for up to five lactations in a population of 2273 Holstein cows. There were additive effects of the mutation (P < 0.05) in favor of the A allele for pregnancy rate, interval from calving to conception, and services per conception. There was no association of genotype with milk production or body weight changes postpartum. The mutation in COQ9 affected ovarian function; the A allele was associated with increased mitochondrial DNA copy number in oocytes, and there were overdominance effects for COQ9 expression in oocytes, follicle number, and antimullerian hormone concentrations. Overall, results show how a gene involved in mitochondrial function is associat... Mostrar Tudo |
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Palavras-Chave: |
COQ9; Oocyte. |
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Thesaurus Nal: |
cattle; genetic variation; mitochondria. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02335naa a2200265 a 4500
001 2072163
005 2023-01-27
008 2017 bl uuuu u00u1 u #d
100 1 $aORTEGA, M. S.
245 $aA single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows.$h[electronic resource]
260 $c2017
520 $aA single missense mutation at position 159 of coenzyme Q9 (COQ9) (G→A; rs109301586) has been associated with genetic variation in fertility in Holstein cattle, with the A allele associated with higher fertility. COQ9 is involved in the synthesis of coenzyme COQ10, a component of the electron transport system of the mitochondria. Here we tested whether reproductive phenotype is associated with the mutation and evaluated functional consequences for cellular oxygen metabolism, body weight changes, and ovarian function. The mutation in COQ9 modifies predicted tertiary protein structure and affected mitochondrial respiration of peripheral blood mononuclear cells. The A allele was associated with low resting oxygen consumption and high electron transport system capacity. Phenotypic measurements for fertility were evaluated for up to five lactations in a population of 2273 Holstein cows. There were additive effects of the mutation (P < 0.05) in favor of the A allele for pregnancy rate, interval from calving to conception, and services per conception. There was no association of genotype with milk production or body weight changes postpartum. The mutation in COQ9 affected ovarian function; the A allele was associated with increased mitochondrial DNA copy number in oocytes, and there were overdominance effects for COQ9 expression in oocytes, follicle number, and antimullerian hormone concentrations. Overall, results show how a gene involved in mitochondrial function is associated with overall fertility, possibly in part by affecting oocyte quality.
650 $acattle
650 $agenetic variation
650 $amitochondria
653 $aCOQ9
653 $aOocyte
700 1 $aWOHLGEMUTH, S.
700 1 $aTRIBULO, P.
700 1 $aSIQUEIRA, L. G. B.
700 1 $aNULL, D. J.
700 1 $aCOLE, J. B.
700 1 $aSILVA, M. V. G. B.
700 1 $aHANSEN, P. J.
773 $tBiology of Reproduction$gv. 96, n. 3, p. 652-663, 2017.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 18 | |
| 1. |  | BELLÉ, C.; KUHN, P. R.; REINEHR, M.; KULCZYNSKI, S. M.; GOMES, C. B. Extratos aquosos de plantas daninhas, aromáticas e oleaginosa no controle de Meloidogyne incognita. In: CONGRESSO BRASILEIRO DE NEMATOLOGIA, 32., 2015, Londrina. Nematologia: problemas emergentes e perspectivas: anais. Londrina: Sociedade Brasileira de Nematologia, 2015. p. 145| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 3. | | FERNANDES, D. S.; SORATTO, R. P.; KULCZYNSKI, S. M.; BISCARO, G. A.; REIS, C. J. dos. Produtividade e qualidade fisiológica de sementes de feijão em conseqüência da aplicação foliar de manganês. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 42, n. 3, p. 419-426, mar. 2007 Título em inglês: Yield and physiological quality of common bean seeds as affected by manganese foliar application.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 5. | | KASPARY, T. E.; LAMEGO, F. P.; BELLÉ, C.; KULCZYNSKI, S. M.; PITTOL, D. Regulador de crescimento na produtividade e qualidade de sementes de aveia-branca. Planta Daninha, Viçosa, MG, v. 33, n. 4, p. 739-750, out./dez. 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 6. | | BELLÉ, C.; KULCZYNSKI, S. M.; KUHN, P. R.; DONINI, L. P.; GOMES, C. B. Reaction of sugarcane genotypes to parasitism of Meloidogyne javanica and Pratylenchus zeae. Revista Caatinga, Mossoró, v. 30, n. 2, p. 530-535, 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 7. | | FERNANDES, A. M.; KULCZYNSKI, S. M.; BARBOSA, M. M. M.; GRANDE, J. P.; GOMES, C. B. Levantamento de fitonematóides em hortas no municípios de Cassilândia-MS. In: CONGRESSO BRASILEIRO DE NEMATOLOGIA, 27., 2007, Goiânia. Anais: programação, palestras, resumos. Goiânia: UFG, 2007. p. 54-55| Tipo: Resumo em Anais de Congresso | Circulação/Nível: -- - -- |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 10. | | BELLÉ, C.; KULCZYNSKI, S. M.; GOMES, C. B.; KUHN, P. R.; LIMA-MEDINA, I. Diversidade de espécies de Meloidogyne em cana-de-açúcar no Rio Grande do Sul, Brasil. In: CONGRESSO BRASILEIRO DE FITOPATOLOGIA, 47.; SIMPÓSIO BRASILEIRO DE MOFO BRANCO, 2014, Londrina. Desafios futuros: anais. Londrina: Sociedade Brasileira de Fitopatologia, 2014. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 11. | | KUHN, P. R.; KULCZYNSKI, S. M.; BELLÉ, C.; TREVISAN, R.; GOMES, C. B. Suscetibilidade de espécies frutíferas, forrageiras e daninhas a duas populações de mesocriconema xenoplax. Nematropica, v. 45, n. 2, p. 279-284, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 12. | | BELLÉ, C.; KULCZYNSKI, S. M; KUHN, P. R.; CARNEIRO, R. M. D. G.; LIMA-MEDINA, I.; GOMES, C. B. First report of Meloidogyne ethiopica parasitizing sugarcane in Brazil. Plant Disease, v. 101, n. 4, p. 635, Apr. 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Clima Temperado; Embrapa Recursos Genéticos e Biotecnologia. |
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| 13. | | KIRSCH, V. G.; KULCZYNSKI, S. M.; GOMES, C. B.; BISOGNIN, A. C.; GABRIEL, M.; BELLÉ, C.; LIMA-MEDINA, I. Caracterização de espéceis de meloidogyne e de helicotylenchus associadas à soja no Rio Grande do Sul. Nematropica, v. 46, n. 2, p. 197-208, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 14. | | BELLE, C.; GOMES, C. B.; KULCZYNSKI, S. M.; KUHN, P. R.; SIGNORINI, C. B.; SILVA, S. D. A. Reação de genótipos de cana-de-açúcar adaptadas ao Rio Grande do Sul ao parasitismo por Meloidogyne javanica. reaction of adapted genotypes to rio grande do sul state to Meloidogyne javanica parasitism. In: CONGRESSO BRASILEIRO DE NEMATOLOGIA, 31., 2013, Cuiabá. Nematoides: desafios e manejo - anais. Cuiabá: Sociedade Brasileira de Namatologia, 2013.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 16. | | KUHN, P. R.; KULCZYNSKI, S. M.; GOMES, C. B.; BELLÉ, C.; KIRSCH, V. G.; GABRIEL, M.; PEDROSO, D. S. Hospedabilidade de plantas frutíferas, forrageiras e daninhas a Mesocriconema xenoplax. In: CONGRESSO BRASILEIRO DE NEMATOLOGIA, 32., 2015, Londrina. Nematologia: problemas emergentes e perspectivas: anais. Londrina: Sociedade Brasileira de Nematologia, 2015. p. 121| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 17. | | GABRIEL, M.; KULCZYNSKI, S. M. K.; SANTOS, M. F. A.; SOUZA, C. F. B.; MUNIZ, M. F. B.; BOITEUX, L. S.; CARNEIRO, R. M. D. G. A novel virulent Brazilian pathotype of Meloidogyne javanica towards the tomato Mi-1.2 gene and pathogenicity to resistant rootstock. Journal of Plant Diseases and Protection, v. 129, p. 1269-1276, 2022.| Tipo: Nota Técnica/Nota Científica |
| Biblioteca(s): Embrapa Hortaliças; Embrapa Recursos Genéticos e Biotecnologia. |
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| 18. | | KULCZYNSKI, S. M.; TOMM, G. O.; CALDERAM, A.; KUHN, P. R.; BELLÉ, C.; KIRSCH, V. G.; PEDROSO, D. S.; WILLE, R. M.; PINHEIRO, M. O.; JASTER, T.; ABREU, C. C.; COSTA, K.; SCARANTTI, V. Reação de genótipos de canola à Leptosphaeria maculans no norte do Rio Grande do Sul. In: SIMPÓSIO LATINO AMERICANO DE CANOLA, 1., 2014, Passo Fundo. Anais... Brasília, DF: Embrapa, 2014. 6 p. Trabalho 2.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Trigo. |
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| Registros recuperados : 18 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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