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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
20/10/2016 |
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Data da última atualização: |
01/04/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVA, V. H. da; REGITANO, L. C. de A.; GEISTLINGER, L.; PÉRTILLE, F.; GIACHETTO, P. F.; BRASSALOTI, R. A.; MOROSINI, N. S.; ZIMMER, R.; COUTINHO, L. L. |
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Afiliação: |
VINICIUS HENRIQUE DA SILVA, USP/ESALQ; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; LUDWIG GEISTLINGER, Ludwig-Maximilians- Universität München; FÁBIO PÉRTILLE, USP/ESALQ; POLIANA FERNANDA GIACHETTO, CNPTIA; RICARDO AUGUSTO BRASSALOTI, USP/ESALQ; NATÁLIA SILVA MOROSINI, USP/ESALQ; RALF ZIMMER, Ludwig-Maximilians- Universität München; LUIZ LEHMANN COUTINHO, USP/ESALQ. |
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Título: |
Genome-wide detection of CNVs and their association with meat tenderness in Nelore cattle. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Plos One, june 2016. |
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DOI: |
10.1371/journal.pone.0157711 |
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Idioma: |
Inglês |
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Conteúdo: |
Brazil is one of the largest beef producers and exporters in the world with the Nelore breed representing the vast majority of Brazilian cattle (Bos taurus indicus). Despite the great adaptability of the Nelore breed to tropical climate, meat tenderness (MT) remains to be improved. Several factors including genetic composition can influence MT. In this article, we report a genome-wide analysis of copy number variation (CNV) inferred from Illumina1 High Density SNP-chip data for a Nelore population of 723 males. We detected >2,600 CNV regions (CNVRs) representing 6.5% of the genome. Comparing our results with previous studies revealed an overlap in 1400 CNVRs (>50%). A total of 1,155 CNVRs (43.6%) overlapped 2,750 genes. They were enriched for processes involving guanosine triphosphate (GTP), previously reported to influence skeletal muscle physiology and morphology. Nelore CNVRs also overlapped QTLs for MT reported in other breeds (8.9%, 236 CNVRs) and from a previous study with this population (4.1%, 109 CNVRs). Two CNVRs were also proximal to glutathione metabolism genes that were previously associated with MT. Genome-wide association study of CN state with estimated breeding values derived from meat shear force identified 6 regions, including a region on BTA3 that contains genes of the cAMP and cGMP pathway. Ten CNVRs that overlapped regions associated with MT were successfully validated by qPCR. Our results represent the first comprehensive CNV study in Bos taurus indicus cattle and identify regions in which copy number changes are potentially of importance for the MT phenotype. MenosBrazil is one of the largest beef producers and exporters in the world with the Nelore breed representing the vast majority of Brazilian cattle (Bos taurus indicus). Despite the great adaptability of the Nelore breed to tropical climate, meat tenderness (MT) remains to be improved. Several factors including genetic composition can influence MT. In this article, we report a genome-wide analysis of copy number variation (CNV) inferred from Illumina1 High Density SNP-chip data for a Nelore population of 723 males. We detected >2,600 CNV regions (CNVRs) representing 6.5% of the genome. Comparing our results with previous studies revealed an overlap in 1400 CNVRs (>50%). A total of 1,155 CNVRs (43.6%) overlapped 2,750 genes. They were enriched for processes involving guanosine triphosphate (GTP), previously reported to influence skeletal muscle physiology and morphology. Nelore CNVRs also overlapped QTLs for MT reported in other breeds (8.9%, 236 CNVRs) and from a previous study with this population (4.1%, 109 CNVRs). Two CNVRs were also proximal to glutathione metabolism genes that were previously associated with MT. Genome-wide association study of CN state with estimated breeding values derived from meat shear force identified 6 regions, including a region on BTA3 that contains genes of the cAMP and cGMP pathway. Ten CNVRs that overlapped regions associated with MT were successfully validated by qPCR. Our results represent the first comprehensive CNV study in Bos taurus indicu... Mostrar Tudo |
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Palavras-Chave: |
CNV; Genômica; Maciez da carne; Nelore. |
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Thesagro: |
Gado Nelore. |
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Thesaurus Nal: |
Meat tenderness. |
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Categoria do assunto: |
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/149047/1/pone.0157711.pdf
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Marc: |
LEADER 02441naa a2200301 a 4500
001 2055112
005 2019-04-01
008 2016 bl uuuu u00u1 u #d
024 7 $a10.1371/journal.pone.0157711$2DOI
100 1 $aSILVA, V. H. da
245 $aGenome-wide detection of CNVs and their association with meat tenderness in Nelore cattle.$h[electronic resource]
260 $c2016
520 $aBrazil is one of the largest beef producers and exporters in the world with the Nelore breed representing the vast majority of Brazilian cattle (Bos taurus indicus). Despite the great adaptability of the Nelore breed to tropical climate, meat tenderness (MT) remains to be improved. Several factors including genetic composition can influence MT. In this article, we report a genome-wide analysis of copy number variation (CNV) inferred from Illumina1 High Density SNP-chip data for a Nelore population of 723 males. We detected >2,600 CNV regions (CNVRs) representing 6.5% of the genome. Comparing our results with previous studies revealed an overlap in 1400 CNVRs (>50%). A total of 1,155 CNVRs (43.6%) overlapped 2,750 genes. They were enriched for processes involving guanosine triphosphate (GTP), previously reported to influence skeletal muscle physiology and morphology. Nelore CNVRs also overlapped QTLs for MT reported in other breeds (8.9%, 236 CNVRs) and from a previous study with this population (4.1%, 109 CNVRs). Two CNVRs were also proximal to glutathione metabolism genes that were previously associated with MT. Genome-wide association study of CN state with estimated breeding values derived from meat shear force identified 6 regions, including a region on BTA3 that contains genes of the cAMP and cGMP pathway. Ten CNVRs that overlapped regions associated with MT were successfully validated by qPCR. Our results represent the first comprehensive CNV study in Bos taurus indicus cattle and identify regions in which copy number changes are potentially of importance for the MT phenotype.
650 $aMeat tenderness
650 $aGado Nelore
653 $aCNV
653 $aGenômica
653 $aMaciez da carne
653 $aNelore
700 1 $aREGITANO, L. C. de A.
700 1 $aGEISTLINGER, L.
700 1 $aPÉRTILLE, F.
700 1 $aGIACHETTO, P. F.
700 1 $aBRASSALOTI, R. A.
700 1 $aMOROSINI, N. S.
700 1 $aZIMMER, R.
700 1 $aCOUTINHO, L. L.
773 $tPlos One, june 2016.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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| 22. |  | LIMA, C. S. M.; VILANOVA, D. S.; GONÇALVES, M. A.; RUFATO, L.; RUFATO, A. de R. Diferentes substratos e recipientes na formação de mudas de Physalis peruviana L. In: SIMPÓSIO NACIONAL DO MORANGO, 5.; ENCONTRO SOBRE PEQUENAS FRUTAS E FRUTAS NATIVAS DO MERCOSUL, 4., 2010, Pelotas. Palestras e resumos... Pelotas: Embrapa Clima Temperado, 2010. p. 180. Resumo.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Uva e Vinho. |
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| 24. | | LUCIANO, R. V.; ALBUQUERQUE, J. A.; RUFATO, L.; MIQUELLUTI, D. J.; WARMLING, M. T. Condições meteorológicas e tipo de solo de solo na composição da uva 'Cabernet sauvignon'. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 48, n. 1, p. 97-104, jan. 2013. Título em inglês: Weather and soil effects on the composition of 'Cabernet Sauvignon' grape.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 35. | | SILVA, L. C. da; RUFATO, L.; KRETZSCHMAR, A. A.; MARCON FILHO, J. L. Raleio de cachos em vinhedos de altitude e qualidade do vinho da cultivar Syrah. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 44, n. 2, p. 148-154, fev. 2009. Título em inglês: Cluster thinning in high altitude vineyards and wine quality from the cultivar Syrah.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 36. | | CARMINATTI, J. F.; MICHELON, M. F.; SANDER, G. F.; RUFATO, A. de R.; RUFATO, L. Raleioquímico de macieiras "Maxigala"' com aplicação de metamitron em diferentes doses e épocas de aplicação. In.:ENCONTRO NACIONAL SOBRE FRUTICULTURA DE CLIMA TEMPERADO, 14., 2015, Fraiburgo, SC. Anais...(v.2 - Resumos). Caçador: Epagri, v. 2 (trabalhos), 2015. p. 49.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Uva e Vinho. |
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| 38. | | RUFATO, A. de R.; PELIZZA, T.; KRETZSCHMAR, A. A.; RUFATO, L. Sistemas de condução de plantas. In: FIORAVANÇO, J. C.; SANTOS, R. S. S. dos (Ed.). Maçã: o produtor pergunta, a Embrapa responde. Brasília, DF: Embrapa, 2013. p. 155-169. (Coleção 500 perguntas, 500 respostas).| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Uva e Vinho. |
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| 40. | | FAGHERAZZI, A. F.; COCCO, C.; ANTUNES, L. E. C.; FAEDI, W.; BARUZZI, G.; RUFATO, L. Novos genótipos de morangos italianos com potencial de cultivo no brasil. In: CONGRESSO BRASILEIRO DE FRUTICULTURA, 22., 2012, Bento Gonçalves. Anais... Bento Gonçalves: SBF, 2012.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Clima Temperado. |
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| Registros recuperados : 95 | |
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