Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
19/02/2016 |
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Data da última atualização: |
03/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
SILVA, A. P. C.; MACÊDO, A. A.; SILVA, T. M. A.; XIMENES, L. C. A.; BRANDAO, H. de M.; PAIXÃO, T. A.; SANTOS, R. L. |
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Afiliação: |
Ana Patrícia C. Silva, UFMG; Auricélio A. Macêdo, UFMG; Teane M. A. Silva, UFMG; Luana C. A. Ximenes, UFMG; HUMBERTO DE MELLO BRANDAO, CNPGL; Tatiane A. Paixão, UFMG; Renato L. Santos, UFMG. |
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Título: |
Protection Provided by an Encapsulated Live Attenuated ?abcBA Strain of Brucella ovis against Experimental Challenge in a Murine Model. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Clinical and Vaccine Immunology, v. 22, n. 7, p. 789-973, 2015. |
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Idioma: |
Inglês |
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Conteúdo: |
This study aimed to evaluate the Brucella ovis ΔabcBA strain as a vaccine candidate in the murine model. BALB/c mice were subcutaneously or intraperitoneally immunized with a single dose or three doses of the B. ovis ΔabcBA strain and then were challenged with wild-type B. ovis. Single or multiple immunizations provided only mild protection, with significantly smaller numbers of wild-type B. ovis CFU in the livers of immunized mice but not in the spleens. Encapsulation of B. ovis ΔabcBA significantly improved protection against experimental challenges in both BALB/c and C57BL/6 mice. Furthermore, immunization with encapsulated B. ovis ΔabcBA markedly prevented lesions in the spleens and livers of experimentally challenged mice. These results demonstrated that the encapsulated B. ovis ΔabcBA strain confers protection to mice; therefore, this strain has potential as a vaccine candidate for rams. |
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Palavras-Chave: |
Vaccine. |
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Thesaurus NAL: |
animal health. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
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245 $aProtection Provided by an Encapsulated Live Attenuated ?abcBA Strain of Brucella ovis against Experimental Challenge in a Murine Model.$h[electronic resource]
260 $c2015
520 $aThis study aimed to evaluate the Brucella ovis ΔabcBA strain as a vaccine candidate in the murine model. BALB/c mice were subcutaneously or intraperitoneally immunized with a single dose or three doses of the B. ovis ΔabcBA strain and then were challenged with wild-type B. ovis. Single or multiple immunizations provided only mild protection, with significantly smaller numbers of wild-type B. ovis CFU in the livers of immunized mice but not in the spleens. Encapsulation of B. ovis ΔabcBA significantly improved protection against experimental challenges in both BALB/c and C57BL/6 mice. Furthermore, immunization with encapsulated B. ovis ΔabcBA markedly prevented lesions in the spleens and livers of experimentally challenged mice. These results demonstrated that the encapsulated B. ovis ΔabcBA strain confers protection to mice; therefore, this strain has potential as a vaccine candidate for rams.
650 $aanimal health
653 $aVaccine
700 1 $aMACÊDO, A. A.
700 1 $aSILVA, T. M. A.
700 1 $aXIMENES, L. C. A.
700 1 $aBRANDAO, H. de M.
700 1 $aPAIXÃO, T. A.
700 1 $aSANTOS, R. L.
773 $tClinical and Vaccine Immunology$gv. 22, n. 7, p. 789-973, 2015.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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