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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
21/11/2012 |
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Data da última atualização: |
21/11/2012 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LESSA, R. C.; CAMPOS, A. H. J. F. M.; FREITAS, C. E. de; SILVA, F. R. da; KOWALSKI, L. P.; CARVALHO, A. L.; VETTORE, A. L. |
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Afiliação: |
ROBERTA C. LESSA, Hospital Sao Paulo.; Antonio Hugo J. F. M. Campos,, Camargo Cancer Hospital, Sao Paulo, SP; Carlos Elias de Freitas, Hospital São Paulo; FELIPE RODRIGUES DA SILVA, CNPTIA; Luiz Paulo Kowalski, A. C. Camargo Cancer Hospital, Sao Paulo, SP; André Lopes Carvalho, Hospital do Cancer, Barretos, SP; André Luiz Vettore, Unifesp. |
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Título: |
Identification of upregulated genes in oral squamous cell carcinomas. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
Head & Neck, 2012. |
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DOI: |
DOI 10.1002/HED |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Background. Oral cancer is the most common subset of head and neck squamous cell carcinomas (HNSCC). These tumors often have an aggressive clinical outcome hallmarked by a propensity for local invasion and regional nodal metastasis. Upregulated genes could be useful as markers for diagnosis, prognosis, and as new drug targets for these tumors. Methods. To identify upregulated genes in oral squamous cell carcinomas (OSSCs), we examined the ORESTES public database and used a quantitative reverse transcription?polymerase chain reaction (qRT-PCR) approach to determine the expression level of selected genes in tumor samples. Results and conclusions. The ORESTES data mining analysis indicated 40 upregulated genes in HNSCC. Nine of these candidate genes were selected for further qRT-PCR validation and 3 of them (ALDOA, AHSA1, and POLQ) were frequently found upregulated in OSCC samples, which may indicate an association of these genes with the carcinogenesis process in this tumor site and they can constitute potential new targets for therapy. |
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Thesaurus Nal: |
genes. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 01652naa a2200217 a 4500
001 1940191
005 2012-11-21
008 2012 bl uuuu u00u1 u #d
024 7 $aDOI 10.1002/HED$2DOI
100 1 $aLESSA, R. C.
245 $aIdentification of upregulated genes in oral squamous cell carcinomas.$h[electronic resource]
260 $c2012
520 $aAbstract: Background. Oral cancer is the most common subset of head and neck squamous cell carcinomas (HNSCC). These tumors often have an aggressive clinical outcome hallmarked by a propensity for local invasion and regional nodal metastasis. Upregulated genes could be useful as markers for diagnosis, prognosis, and as new drug targets for these tumors. Methods. To identify upregulated genes in oral squamous cell carcinomas (OSSCs), we examined the ORESTES public database and used a quantitative reverse transcription?polymerase chain reaction (qRT-PCR) approach to determine the expression level of selected genes in tumor samples. Results and conclusions. The ORESTES data mining analysis indicated 40 upregulated genes in HNSCC. Nine of these candidate genes were selected for further qRT-PCR validation and 3 of them (ALDOA, AHSA1, and POLQ) were frequently found upregulated in OSCC samples, which may indicate an association of these genes with the carcinogenesis process in this tumor site and they can constitute potential new targets for therapy.
650 $agenes
700 1 $aCAMPOS, A. H. J. F. M.
700 1 $aFREITAS, C. E. de
700 1 $aSILVA, F. R. da
700 1 $aKOWALSKI, L. P.
700 1 $aCARVALHO, A. L.
700 1 $aVETTORE, A. L.
773 $tHead & Neck, 2012.
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