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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
02/10/2023 |
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Autoria: |
DOBSON, C. |
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Título: |
Changes in the protein content of the serum and intestinal mucus of sheep with reference to the histology of the gut and immunologycal response to Oephagostomum columbianum infections. |
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Ano de publicação: |
1967 |
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Fonte/Imprenta: |
Parasitology, v. 57, n. 2, p. 201-219, 1967. |
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DOI: |
10.1017/s0031182000072036. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Sheep infected with Oesophagostomum columbianum showed anorexia, loss of weight, diarrhoea and macroscopically obvious oedema and inflammation of the alimentary tract. Arthus-like lesions caused by the larvae developed particularly in the large intestine. The gross immunological responses of the sheep were associated with antibodies in greater titre within the mucus of the gut than in the serum. Acquired immunity was manifest through an antibody-antigen reaction which was localized mostly in the large intestine and which involved proliferation of the lymphoid tissue of the gut and an increased synthesis of protein. Lower titres of antibody in serum than in mucus may indicate leakage of antibody away from the gut. The direct effects of antibody were established by the respiratory inhibition of the 3rd-stage larvae. The presence of antibody was associated with particularly high concentrations of / globulin after first and /? and y globulins after second infection. Specific antibody was demonstrated in these protein fractions by blockage of electrophoretic movement by larval antigen in the buffer. The antibody-antigen reaction may act as a trigger which releases the nonspecific effects of excess mucus production and oedema which causes mechanical dislodgement of the infection. The natural and specific respiratory inhibitory effects of mucus on the worm would facilitate this dislodgement process. The greatest cellular reactions occurred where there was an active infection. Usually these reactions were associated with oedema, hyperaemia and an increase in the size of the mesenteric lymph nodes. The lymphoid tissue of the mesenteries and gut hypertrophied, and there were increases in the number of circulating white cells, particularly in the agranulocyte and eosinophil leucocyte counts. The numbers of circulating neutrophil leucocytes fell after infection; this may be associated with the occurrence of Arthus-like lesions in the gut wall. Globule leucocytes and mast cells increased particularly in the part of the gut occupied by the adult worm. Their presence was associated with the transfer of globulins into the gut lumen, increased mucin production and oedema of the gut. The marked eosinophilia was most evident within the infected tissues and was related to the hypersensitive nature of the reactions. It was concluded that the reactions of the sheep to 0. columbianum were local ones centred on the alimentary tract. Inhibition of larval respiration was due to a non-specific factor in mucus and to the effects of specific antibody coating the cuticle and reducing oxygen uptake; antibody was also demonstrated by complement fixation, passive haemagglutination and passive cutaneous anaphylaxis, but not by the precipitin reaction. This work was supported by a grant from the Australian Wool Board. I should like to thank Professor J. F. A. Sprent for his continued interest in this work, Mr H. Kunze for his conscientious assistance and Mrs A. McKeown and Miss S. McFeeter for preparing the histological material. MenosAbstract: Sheep infected with Oesophagostomum columbianum showed anorexia, loss of weight, diarrhoea and macroscopically obvious oedema and inflammation of the alimentary tract. Arthus-like lesions caused by the larvae developed particularly in the large intestine. The gross immunological responses of the sheep were associated with antibodies in greater titre within the mucus of the gut than in the serum. Acquired immunity was manifest through an antibody-antigen reaction which was localized mostly in the large intestine and which involved proliferation of the lymphoid tissue of the gut and an increased synthesis of protein. Lower titres of antibody in serum than in mucus may indicate leakage of antibody away from the gut. The direct effects of antibody were established by the respiratory inhibition of the 3rd-stage larvae. The presence of antibody was associated with particularly high concentrations of / globulin after first and /? and y globulins after second infection. Specific antibody was demonstrated in these protein fractions by blockage of electrophoretic movement by larval antigen in the buffer. The antibody-antigen reaction may act as a trigger which releases the nonspecific effects of excess mucus production and oedema which causes mechanical dislodgement of the infection. The natural and specific respiratory inhibitory effects of mucus on the worm would facilitate this dislodgement process. The greatest cellular reactions occurred where there was an active infect... Mostrar Tudo |
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Palavras-Chave: |
Drug effects; Immune Sera; Oesophagostomiasis; Passive Cutaneous Anaphylaxis. |
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Thesagro: |
Helminto; Imunologia; Ovino; Parasitologia. |
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Thesaurus Nal: |
Antibodies; Complement fixation tests; Hemagglutination tests; Immunology; Mucus; Nematoda; Oxygen consumption; Parasitology; Pharmacology; Sheep diseases. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 04128naa a2200349 a 4500
001 1520364
005 2023-10-02
008 1967 bl uuuu u00u1 u #d
024 7 $a10.1017/s0031182000072036.$2DOI
100 1 $aDOBSON, C.
245 $aChanges in the protein content of the serum and intestinal mucus of sheep with reference to the histology of the gut and immunologycal response to Oephagostomum columbianum infections.$h[electronic resource]
260 $c1967
520 $aAbstract: Sheep infected with Oesophagostomum columbianum showed anorexia, loss of weight, diarrhoea and macroscopically obvious oedema and inflammation of the alimentary tract. Arthus-like lesions caused by the larvae developed particularly in the large intestine. The gross immunological responses of the sheep were associated with antibodies in greater titre within the mucus of the gut than in the serum. Acquired immunity was manifest through an antibody-antigen reaction which was localized mostly in the large intestine and which involved proliferation of the lymphoid tissue of the gut and an increased synthesis of protein. Lower titres of antibody in serum than in mucus may indicate leakage of antibody away from the gut. The direct effects of antibody were established by the respiratory inhibition of the 3rd-stage larvae. The presence of antibody was associated with particularly high concentrations of / globulin after first and /? and y globulins after second infection. Specific antibody was demonstrated in these protein fractions by blockage of electrophoretic movement by larval antigen in the buffer. The antibody-antigen reaction may act as a trigger which releases the nonspecific effects of excess mucus production and oedema which causes mechanical dislodgement of the infection. The natural and specific respiratory inhibitory effects of mucus on the worm would facilitate this dislodgement process. The greatest cellular reactions occurred where there was an active infection. Usually these reactions were associated with oedema, hyperaemia and an increase in the size of the mesenteric lymph nodes. The lymphoid tissue of the mesenteries and gut hypertrophied, and there were increases in the number of circulating white cells, particularly in the agranulocyte and eosinophil leucocyte counts. The numbers of circulating neutrophil leucocytes fell after infection; this may be associated with the occurrence of Arthus-like lesions in the gut wall. Globule leucocytes and mast cells increased particularly in the part of the gut occupied by the adult worm. Their presence was associated with the transfer of globulins into the gut lumen, increased mucin production and oedema of the gut. The marked eosinophilia was most evident within the infected tissues and was related to the hypersensitive nature of the reactions. It was concluded that the reactions of the sheep to 0. columbianum were local ones centred on the alimentary tract. Inhibition of larval respiration was due to a non-specific factor in mucus and to the effects of specific antibody coating the cuticle and reducing oxygen uptake; antibody was also demonstrated by complement fixation, passive haemagglutination and passive cutaneous anaphylaxis, but not by the precipitin reaction. This work was supported by a grant from the Australian Wool Board. I should like to thank Professor J. F. A. Sprent for his continued interest in this work, Mr H. Kunze for his conscientious assistance and Mrs A. McKeown and Miss S. McFeeter for preparing the histological material.
650 $aAntibodies
650 $aComplement fixation tests
650 $aHemagglutination tests
650 $aImmunology
650 $aMucus
650 $aNematoda
650 $aOxygen consumption
650 $aParasitology
650 $aPharmacology
650 $aSheep diseases
650 $aHelminto
650 $aImunologia
650 $aOvino
650 $aParasitologia
653 $aDrug effects
653 $aImmune Sera
653 $aOesophagostomiasis
653 $aPassive Cutaneous Anaphylaxis
773 $tParasitology$gv. 57, n. 2, p. 201-219, 1967.
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| 1. |  | HASEGAWA, M. Y.; LARA, M. do C. C. S. H.; GAETA, N. C.; MARQUES, J. A.; RIBEIRO, B. L. M.; ROSSI, R. S.; MARQUES, E. C.; GREGORY, L. Transmissibilidade de lentivírus de pequenos ruminantes para cabritos e cabras adultas por meio de sêmen infectado experimentalmente. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 8, p. 805-812, ago. 2017. Título em inglês: Transmissibility of Small Ruminants Lentivirus in kids by experimentally infected semen.| Biblioteca(s): Embrapa Unidades Centrais. |
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