|
Registro Completo |
|
Biblioteca(s): |
Embrapa Mandioca e Fruticultura. |
|
Data corrente: |
25/11/2021 |
|
Data da última atualização: |
25/11/2021 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
MIRANDA, Í. K. S. P. B.; SANTANA, F. R.; CAMILLOTO, G. P.; DETONI, C. B.; SOUZA, F. V. D.; CABRAL-ALBUQUERQUE, E. C. de M.; ALVES, S. L.; NECO, G. L.; LIMA, F. O. de; ASSIS, S. A. de. |
|
Afiliação: |
ÍNGARA KEISLE SÃO PAULO BARRETTO MIRANDA, UEFS; FERNANDO ROCHA SANTANA, UEFS; GEANY PERUCH CAMILLOTO, UEFS; CASSIA BRITTO DETONI; FERNANDA VIDIGAL DUARTE SOUZA, CNPMF; ELAINE CHRISTINE DE MAGALHÃES CABRAL-ALBUQUERQUE, UFBA; SARA LIMA ALVES, UEFS; GLAUCIA LAIS NECO, UEFS; FLÁVIA OLIVEIRA DE LIMA, UEFS; SANDRA APARECIDA DE ASSIS. |
|
Título: |
Development of membranes based on carboxymethyl cellulose/acetylated arrowroot starch containing bromelain extract carried on nanoparticles and liposomes. |
|
Ano de publicação: |
2021 |
|
Fonte/Imprenta: |
Journal of Pharmaceutical Sciences, 2021. |
|
ISSN: |
1520-6017 |
|
DOI: |
10.1016/j.xphs.2021.02.031 |
|
Idioma: |
Inglês |
|
Notas: |
Online first. |
|
Conteúdo: |
Polymeric membranes have been used in several applications, including their use as curatives in cutaneous wounds. Bromelain has long been used for anti-inflammatory purposes, so the objective of this work was to produce carboxymethylcellulose-acetylated blends, incorporate bromelain, characterize the systems, compare the blends with bromelain loaded in nanoparticles and liposomes and, finally, to evaluate their healing potential. Four membrane formulations were produced by solvent evaporation: the control, membranes containing free bromelain, bromelain-loaded nanoparticles (NPs) and bromelain-loaded liposomes (LIPs). The enzyme concentration was the same for all formulations. Transparent, flexible and intact films were obtained. The membranes containing free bromelain, bromelain-loaded NPs and bromelain-loaded LIPs had higher water content, lower water vapor permeability and maximum tensile strength, and greater elongation at rupture. The capacity to absorb simulated exudate was higher in samples containing free bromelain, and bioadhesion was reduced in the presence of free bromelain compared to the control. An in vivo assay was performed to verify the membranes' healing potential. Histological analysis revealed no edema on the 14th day in animals treated with membranes containing bromelain-loaded NPs and LIPs. |
|
Thesaurus Nal: |
Carbon nanoparticles; Liposomes (artificial); Nanoparticles. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 02289naa a2200301 a 4500
001 2136602
005 2021-11-25
008 2021 bl uuuu u00u1 u #d
022 $a1520-6017
024 7 $a10.1016/j.xphs.2021.02.031$2DOI
100 1 $aMIRANDA, Í. K. S. P. B.
245 $aDevelopment of membranes based on carboxymethyl cellulose/acetylated arrowroot starch containing bromelain extract carried on nanoparticles and liposomes.$h[electronic resource]
260 $c2021
500 $aOnline first.
520 $aPolymeric membranes have been used in several applications, including their use as curatives in cutaneous wounds. Bromelain has long been used for anti-inflammatory purposes, so the objective of this work was to produce carboxymethylcellulose-acetylated blends, incorporate bromelain, characterize the systems, compare the blends with bromelain loaded in nanoparticles and liposomes and, finally, to evaluate their healing potential. Four membrane formulations were produced by solvent evaporation: the control, membranes containing free bromelain, bromelain-loaded nanoparticles (NPs) and bromelain-loaded liposomes (LIPs). The enzyme concentration was the same for all formulations. Transparent, flexible and intact films were obtained. The membranes containing free bromelain, bromelain-loaded NPs and bromelain-loaded LIPs had higher water content, lower water vapor permeability and maximum tensile strength, and greater elongation at rupture. The capacity to absorb simulated exudate was higher in samples containing free bromelain, and bioadhesion was reduced in the presence of free bromelain compared to the control. An in vivo assay was performed to verify the membranes' healing potential. Histological analysis revealed no edema on the 14th day in animals treated with membranes containing bromelain-loaded NPs and LIPs.
650 $aCarbon nanoparticles
650 $aLiposomes (artificial)
650 $aNanoparticles
700 1 $aSANTANA, F. R.
700 1 $aCAMILLOTO, G. P.
700 1 $aDETONI, C. B.
700 1 $aSOUZA, F. V. D.
700 1 $aCABRAL-ALBUQUERQUE, E. C. de M.
700 1 $aALVES, S. L.
700 1 $aNECO, G. L.
700 1 $aLIMA, F. O. de
700 1 $aASSIS, S. A. de
773 $tJournal of Pharmaceutical Sciences, 2021.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Mandioca e Fruticultura (CNPMF) |
|
