01501naa a2200241 a 450000100080000000500110000800800410001902400340006010000210009424501610011526000090027652007270028565300110101270000220102370000210104570000170106670000190108370000190110270000190112170000190114070000200115977300800117919678832014-02-12       2013    bl uuuu     u00u1 u    #d7 a10.1186/1472-6882-13-2492DOI1 aRODRIGUES, I. A.  aIn vitro cytocidal effects of the essential oil from Croton cajucara (red sacaca) and its major constituent 7- hydroxycalamenene against Leishmania chagasi.  c2013  aVisceral leishmaniasis is the most serious form of leishmaniasis and can be lethal if left untreated. Currently available treatments for these parasitic diseases are frequently associated to severe side effects. The leaves of Croton cajucara are used as an infusion in popular medicine to combat several diseases. Previous studies have demonstrated that the linalool-rich essential oil from C. cajucara (white sacaca) is extremely efficient against the tegumentary specie Leishmania amazonensis. In this study, we investigated the effects of the 7-hydroxycalamenene-rich essential oil from the leaves of C. cajucara (red sacaca) against Leishmania chagasi, as well as on the interaction of these parasites with host cells.  aSacaca1 aAZEVEDO, M. M. B.1 aCHAVES, F. C. M.1 aBIZZO, H. R.1 aCORTE-REAL, S.1 aALVIANO, D. S.1 aALVIANO, C. S.1 aROSA, M. S. S.1 aVERMELHO, A. B.  tBMC Complementary and Alternative Medicinegv. 13, n. 1, p. 249, Oct. 2013.