01357nam a2200265 a 450000100080000000500110000800800410001910000210006024501990008126001800028030000190046050000390047952003510051865000160086965000220088565000130090765000230092065300350094365300240097865300220100270000150102470000160103970000160105570000200107110092962022-05-17       2006    bl uuuu     u00u1 u    #d1 aFERRAZ, L. F. C.  aMolecular homologous modeling of 3B-HSD2 mutant enzymebstructure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.  aIn: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 14.; ANNUAL AB3C CONFERENCE, 2., 2006, Fortaleza. Conference Program... Fortaleza: ISCBc2006  aNão paginado.  aISMB, X-MEETING 2006. Poster D-12.  aShort abstract: We describe the mutation Pro222GIn in HSD3B2 gene on a patient with congenital adrenal hyperplasia. Molecular modeling of 3B-HSD2 mutant allowed us to identify critical role of residue Pro222 on the folding pattern and catalytic activity of the enzyme. The proposed models correlate with the experimental data previously reported.  aHyperplasia  aMolecular Biology  aMutation  aBiologia molecular  aHiperplasia adrenal congenital  aModelagem molecular  aMutação gênica1 aSOARDI, F.1 aFALCÃO, P.1 aNESHICH, G.1 aMELLO, M. P. de