02033naa a2200205 a 450000100080000000500110000800800410001902400500006010000230011024500640013326000090019752014510020665000120165770000210166970000220169070000170171270000170172970000180174677300630176418671712021-04-10       2010    bl uuuu     u00u1 u    #d7 ahttp://dx.doi.org/10.1055/s-0029-12409382DOI1 aPINTO, A. C. da S.  aPiper peltatumbbiomass and 4-nerolidylcatechol production.  c2010  aPiper peltatum L. is used for the treatment of inflammation, malaria, and other ailments. 4-Nerolidylcatechol (4-NC) is a valuable natural product that has important anti-inflammatory, antima-larial, and antioxidant properties. 4-NC is a component of P. peltatumand P. umbellatum extracts, which are used in cosmetics.The aim of this work was to evaluate the production of plant biomass and the production of 4-NC in roots of cultivated P. peltatumover a full life cycle. Seedlings were produced in a greenhouse and then transplanted. The weight of dry plant parts (leaves, stems, roots, and inflorescences); numbers of stems, leaves, and inflorescences; and the leaf-to-stem ratio were evaluated at intervals of 60 days after transplanting (DAT). Extracts were prepared using 1:1 ethanol-chloroform and an ultra sound bath. Roots, leaves, and inflorescences contained 4-NC according toTLC photo densitometry analysis. Quantification of 4-NC in root extracts was performed using HPLC?DAD analysis. Per-hectare production of 4-NC by roots was estimated based on quantitativ e HPLC analysis and biomass data. Optimal per-hectare yields of 4-NC were obtained by harvesting roots between 350 and 400 DAT. In this period, the average yield was 27 kg 4-NC per hectare. Importantly, at the time of maximal overall production of root biomass (470 DAT), there was a decrease in the production of 4-NC(23.8 kg/ha), probably due to the on set of senescence.  aPimenta1 aCHAVES, F. C. M.1 aSANTOS, P. A. dos1 aNUNEZ, C. V.1 aTADEI, W. P.1 aPOHLIT, A. M.  tPlanta Medica, New Yorkgv. 76, n. 13, p. 1473-1475, 2010.