01702naa a2200289 a 450000100080000000500110000800800410001910000160006024500960007626000090017252009410018165000110112265000150113365000150114865000150116365000090117865000110118765000200119870000180121870000150123670000160125170000160126770000170128370000160130070000180131677300780133417997852017-03-31       1997    bl ---       0--  u    #d1 aLANUSSE, C.  aComparative plasma disposition kinetics of ivermectin, moxidectin and doramectin in cattle.  c1997  aThe persistance of the broad-spectrum antiparasitic activity of endectocide compounds relies on their disposition kinetics and pattern of plasma/tissues exchange in the host. This study evaluates the comparative plasma disposition kinetics of ivermectin (IVM), moxidectin (MXD) and doramectin (DRM) in cattle treated with commercially available injectable formulations. Twelve (12) parasite-free male Hereford calves (180-210 kg) grazing on pasture were allocated into three groups of four animals each. Animals in each group received either IVM (Ivomec 1%, MSD AGVET, Rahway, NJ, USA), MXI) (Cydectin 1%, American Cyanamid, Wayne, NJ, USA) or DRM (Dectomax 1%, Pfizer Inc., New York, USA) by subcutaneous injection at a dose of 200 ug/kg. Jugular blood samples were collected from 1 h to 80 days post-treatment, and plasma extracted, derivated and analysed by high performance liquid chromatography (HPLC) using fluorescence detection.  acattle  adoramectin  aivermectin  amoxidectin  aGado  aPlasma  aSanidade Animal1 aLIFSCHITZ, A.1 aVIRKEL, G.1 aALVAREZ, L.1 aSANCHEZ, S.1 aSUTRA, J. F.1 aGALTIER, P.1 aALVINERIE, M.  tJournal of Veterinary Pharmacology and Therapeuticsgv.20, p.91-99, 1997.