01561naa a2200301 a 450000100080000000500110000800800410001910000170006024501120007726000090018952007470019865000130094565000120095865000170097065000120098765000130099965000210101265300160103370000200104970000180106970000190108770000210110670000150112770000220114270000180116470000200118277300570120216784532015-01-06       2006    bl uuuu     u00u1 u    #d1 aFUKUMASU, H.  aChemopreventive effects of Paullinia cupana Mart var. sorbilis, the guarana, on mouse hepatocarcinogenesis.  c2006  aGuarana (Paullinia cupana) is originally front Amazon, Brazil. Its effects on mouse hepatocarcinogenesis have been investigated in this study. Mice were treated with N-nitrosodiethylamine (DEN), received three different doses of P. cupana added to commercial food, and euthanized after 25 weeks. Gross lesions were quantified, and preneoplastic lesions (PNL) were histologically measured. Cellular proliferation was evaluated by immunobloting for the proliferating cell nuclear antigen (PCNA). The incidence and multiplicity of macroscopic lesions were reduced. The PNL number and PCNA expression were reduced in the highest P. cupana dose. According to these results, guarana presented inhibitory effects on DEN hepatocarcinogenesis in mice.  aCafeína  aCâncer  aCarcinôgeno  aFígado  aGuaraná  aPaullinia Cupana  aPrevenção1 aSILVA, T. C. da1 aAVANZO, J. L.1 aLIMA, C. E. de1 aMACKOWIAK, I. I.1 aATROCH, A.1 aSPINOSA, H. de S.1 aMORENO, F. S.1 aDAGLI, M. L. Z.  tCancer Lettersgv. 233, n. 1, p. 158-164, fev. 2006.