01826naa a2200241 a 450000100080000000500110000800800410001910000200006024500630008026000090014352012090015265000110136165000110137265000120138365000210139565000180141665000100143465000090144470000250145370000190147870000210149777300660151815971892004-08-03       2000    bl ---       0--  u    #d1 aTOKARNIA, C. H.  aOutbreak of copper poisoning in cattle fed poultry litter.  c2000  aIn a feedlot of about 1.000 head o cattle, 146 animals died within a period of a few months affected by a disease  characterized by anorexia, icterus, hemoglobinuria, constipation, or diahrrea.  The clinical course of the disease lasted a few days. Postmortem findings were generalized icterus and a yellow discolored liver. The kidneys were dark brown, and the urinary bladder was filled with urine of the same dark-brown color. The main histopathological findings were centrolobular coagulative necrosis, apoptosis, bilestasis, and proliferation of bile ducts in the portal space. Changes in the kidneys included nephrosis and the presence of bile and precipitates, and cylinders of albumin and hemoglobin in the uriniferous tubules. Livers samples, collected from 3 animals on which postmortem examinations were perfomed, had 2,008, 2,783 and 4,906 ppm copper in their dry matter. Two samples of poultry litter fed to the cattle contained 362 and 323 ppm copper. The green forage that formed the rest of their feed only had 4.7 ppm copper. Copper poisoning was diagnosed, most probaly caused by feeding litter from poultry that had been fed a ration treated with copper sulfate to avoid aspergillosis.  acattle  acopper  apoultry  aAnimal Domestico  aAve Domestica  aCobre  aGado1 aDÖBEREINER, Jürgen1 aPEIXOTO, P. V.1 aMORAES, S. da S.  tVeterinary and Human Toxicologygv. 42, n. 2, p. 92-95, 2000.