02408nam a2200289 a 450000100080000000500110000800800410001910000170006024501400007726001800021730000190039750000200041652013900043665000190182665000230184565000220186865300200189065300290191065300120193965300610195170000150201270000190202770000180204670000190206470000190208370000160210215762862020-01-15       2009    bl uuuu     u00u1 u    #d1 aSALIM, J. A.  aMSSPba web-based application for analysis of selected parameter from multiple structures in a graphical manner.h[electronic resource]  aIn: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 5., 2009, Angra dos Reis. Abstracts book... Angra dos Reis: ABBCBc2009  aNão paginado.  aX-Meeting 2009.  aThe Blue Star Sting?s module Multiples Structures Selected Parameter (MSSP) is software developed in Java and Perl programming languages. It allows comparing, in a graphical manner, a selected parameter out of a total of 150 parameters in a different protein structures previously aligned in a simple intuitive plot. From a local database containing more than 60,000 proteins structures users can choose a single protein structure or a set of them. First, the structures are aligned using a specific algorithm and than MSSP does a XY plot, where X represents the residues position and Y the selected parameter values for selected aligned structures. The structural alignment is obtained with the Matching Molecular Models Obtained from Theory (MAMMOTH) software using the version able to align multiples structures called MAMMOTH-mult. Observing the alignments in MSSP plot for a selected parameter is possible see how good an alignment is by observation of the incidence of peaks and valleys in the graphic, and so an insertion of gaps can improve the alignment to optimist incidences of this peaks and valleys. Of course a statistical computation is needed to optimize insertion of gaps and an analysis of a set of parameters is also needed. However with a good alignment algorithm and MSSP it is possible to create a more efficient algorithm to make optimized structural alignments.  aBioinformatics  aMolecular dynamics  aProtein structure  aBioinformática  aEstruturas de proteínas  aMAMMOTH  aMatching Molecular Models Obtained from Theory (MAMMOTH)1 aMAZONI, I.1 aMANCINI, A. L.1 aMORAES, F. R.1 aJARDINE, J. G.1 aNESHICH, I. P.1 aNESHICH, G.