01338naa a2200205 a 450000100080000000500110000800800410001910000190006024501010007926000090018052007490018965000170093865000180095565000140097365300250098765300280101265300130104070000200105377300590107315172401996-09-12       1993    bl uuuu     u00u1 u    #d1 aLANUSSE, C. E.  aRelationship between pharmacological properties and clinical efficacy of ruminant anthelmintics.  c1993  aThe purpose of this review article is to establish a relationship between pharmacological properties and clinical efficacy of the most widely used broad-spectrum veterinary anthelmintics. The impact of drug  pharmacokinetics/pharmacodynamics on anthelmintic efficacy and resistance is discussed. We review the clinical pharmacokinetics of the currently available anthelmintics used in livestock-imidazothiazoles, tetrahydropyrimidines, benzimidazoles/pro-benzimidazoles, salicylanilides (closantel) and a avermectin-type compounds. Understanding the pharmacokinetic and metabolic behaviour of broad-spectrum anthelmintics in the host, and factors modulating that behaviour, is highly iimportant for maximizing anthelmintic utility and efficacy.  aparasitology  aParasitologia  aRuminante  aAnthelmintic control  aControle antihelmintico  aRuminant1 aPRICHARD, R. K.  tVeterinary Parasitologygv.49, n.2-4, p.123-158, 1993.