02619naa a2200301 a 450000100080000000500110000800800410001902400520006010000200011224502140013226000090034652016600035565000100201565000100202565000160203565000120205165000210206370000200208470000190210470000200212370000220214370000240216570000150218970000170220470000190222170000190224077300580225921602742023-12-27       2023    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1007/s11011-023-01175-w2DOI1 aMELLO, J. E. DE  aTherapeutic potential of blackberry extract in the preventing memory defcits and neurochemical alterations in the cerebral cortex, hippocampus and cerebellum of a rat model with amnesia.h[electronic resource]  c2023  aThe blackberry (Rubus sp.) is a popular fruit that has a high concentration of phenolic compounds. Pharmacological investigations have demonstrated the important biological activities of the blackberry extract, such as neuroprotective actions. This study aimed to evaluate the efects of blackberry extract on memory and neurochemical parameters in rats subjected to scopolamine (SCO)-induced amnesia. Male rats were divided into fve groups: I, control (saline); II, SCO; III, SCO +Rubus sp. (100 mg/kg); IV, SCO+Rubus sp. (200 mg/kg); and V, SCO+donepezil (5 mg/kg). Blackberry extract and donepezil were orally administered for 10 days. On day 11, group I received saline, and groups II, III, IV, and V received SCO (1 mg/kg) intraperitoneally after object recognition behavioral training. Twenty-four hours after the training session, animals were subjected to an object recognition test. Finally, the animals were euthanized, and the cerebral cortex, hippocampus, and cerebellum were collected to evaluate the oxidative stress and acetylcholinesterase (AChE) activity. Rubus sp. extract prevented memory impairment induced by SCO in a manner similar to that of donepezil. Additionally, Rubus sp. extract and donepezil prevented the increase in AChE activity induced by SCO in all the evaluated brain structures. SCO induced oxidative damage in the cerebral cortex, hippocampus, and cerebellum, which was prevented by Rubus sp. and donepezil. Our results suggest that the antioxidant and anticholinesterase activities of Rubus sp. are associated with memory improvement; hence, it can potentially be used for the treatment of neurodegenerative diseases.  aRubus  aAmora  aAmora Preta  aExtrato  aExtrato de Fruta1 aLUDUVICO, K. P.1 aSANTOS, A. DOS1 aTEIXEIRA, F. C.1 aCARDOSO, J. DE S.1 aAGUIAR, M. S. S. DE1 aCUNICO, W.1 aVIZZOTTO, M.1 aSTEFANELLO, F.1 aSPANEVELLO, R.  tMetabolic Brain Diseasegv. 38, p. 1261–1272, 2023.