02405naa a2200349 a 450000100080000000500110000800800410001902200140006002400570007410000290013124501370016026000090029752013780030665000110168465000220169565000170171765000120173465000110174665000140175765300200177165300140179165300210180565300130182665300220183965300240186170000200188570000170190570000230192270000220194570000220196777300660198921574892023-10-25       2023    bl uuuu     u00u1 u    #d  a1678-46857 ahttps://doi.org/10.1590/1678-4685-GMB-2023-00842DOI1 aDINIZ SOBRINHO, F. de A.  aCapra hircus outliers markers in Brazilbsearching for genomic regions under the action of natural selection.h[electronic resource]  c2023  aIdentifying genome regions subject to selection in local breeds of Brazil is an opportunity to elucidate the C. hircus genome plasticity, flowing the colonization history of the country. Using SNP Bead Chip Illumina 50K genotyping of Brazilian Anglo-Nubian (standardized breed) and Marota (local endangered population from the semiarid area of Brazil) to show outliers loci in genome regions subject to selection. After applying data quality control, 45,600 SNPs were included in this investigation. Principal component analysis (PCAdapt) and FDIST2 analysis signalized 14 genomic regions more affected by selection in the Brazilian dry zone environment. The genome study signalized regions that are close to the sequences of genes related to growth and embryonic skeletal development (FGF12, AMPD2, OSTN). In addition, flagged regions close to the genes UTSB2 and SLC5A2 contribute to research on functional adaptation with low water needs and poor nutritive diet to survive. Both genes encode proteins that act on osmotic pathways and avoid cell flooding on stress cell responses. Further studies on the genetic role and involvement of these outliers? genomic regions, building a robust conceptual high-resolution map of natural selection drives, help to achieve hardiness candidate genes linked to the evolutionary history of Capra hircus in the semiarid area of Brazil.  aGenome  aNatural selection  aCapra Hircus  aCaprino  aGenoma  aSeleção  aCandidate genes  aHardiness  aNon-neutral loci  aOutliers  aSeleção natural  aTropical adaptation1 aMOURA, J. de O.1 aBAJAY, M. M.1 aCASTELO BRANCO, L.1 aBEZERRA, R. D. S.1 aARAÚJO, A. M. de  tGenetics and Molecular Biologygv. 46, n. 3, e20230084, 2023.