02062naa a2200325 a 450000100080000000500110000800800410001902400430006010000200010324501110012326000090023452011160024365000190135965000110137865300250138965300200141465300160143465300270145065300250147765300200150265300500152270000140157270000200158670000160160670000180162270000130164070000230165370000190167677300410169521539502023-05-24       2023    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.3390/v150512002DOI1 aTREVISOL, I. M.  aPathogenicity of GI-23 avian infectious bronchitis virus strain isolated in Brazil.h[electronic resource]  c2023  aAbstract: IBV variants belonging to the GI-23 lineage have circulated since 1998 in the Middle East and have spread to several countries over time. In Brazil, the first report of GI-23 occurred in 2022. The study aimed to evaluate the in vivo pathogenicity of exotic variant GI-23 isolates. Biological samples were screening by real-time RT-PCR and classified in to GI-1 or G1-11 lineages. Interestingly, 47.77% were not classified in these lineages. Nine of the unclassified strains were sequenced and showed a high similarity to the GI-23 strain. All nine were isolated and three, were studied for pathogenicity. At necropsy, the main observations were the presence of mucus in the trachea and congestion in the tracheal mucosa. In addition, lesions on the tracheas showed marked ciliostasis, and the ciliary activity confirmed the high pathogenicity of isolates. This variant is highly pathogenic to the upper respiratory tract and can cause severe kidney lesions. This study confirm a circulation of GI-23 strain in the country and report, to first time, the isolation of an exotic variant of IBV in Brazil.  aDoença Animal  aFrango  aBrazil GI-23 isolate  aChicken disease  aIBV variant  aPatogenicidade da Cepa  aS1 complete sequence  aVariante do IBV  aVírus da Bronquite Infecciosa Aviária GI-231 aCARON, L.1 aMORES, M. A. Z.1 aRECH, D. V.1 aZANI, G. da S1 aBACK, A.1 aMARCHESI, J. A. P.1 aESTEVES, P. A.  tVirusesgv. 15, n. 5, p. 1200, 2023.