02311naa a2200277 a 450000100080000000500110000800800410001902400520006010000230011224501380013526000090027352014870028265000110176965000200178065000130180065300150181365300130182870000180184170000160185970000230187570000190189870000190191770000250193670000250196177300470198621529542023-08-22       2023    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1007/s00335-023-09989-w2DOI1 aROCHA, R. de F. B.  aRuns of homozygosity and signatures of selection for number of oocytes and embryos in the Gir Indicine cattle.h[electronic resource]  c2023  aRuns of homozygosity (ROH) and signatures of selection are the results of selection processes in livestock species that have been shown to afect several traits in cattle. The aim of the current work was to verify the profle of ROH and inbreeding depression in the number of total (TO) and viable oocytes (VO) and the number of embryos (EMBR) in Gir Indicine cattle. In addition, we aim to identify signatures of selection, genes, and enriched regions between Gir subpopulations sorted by breeding value for these traits. The genotype fle contained 2093 animals and 420,718 SNP markers. Breeding values used to sort Gir animals were previously obtained. ROH and signature of selection analyses were performed using PLINK software, followed by ROH-based (FROH) and pedigree-based inbreeding (Fped) and a search for genes and their functions. An average of 50±8.59 ROHs were found per animal. ROHs were separated into classes according to size, ranging from 1 to 2 Mb (ROH1?2Mb: 58.17%), representing ancient inbreeding, ROH2?4Mb (22.74%), ROH4-8Mb (11.34%), ROH8-16Mb (5.51%), and ROH&gt16Mb (2.24%). Combining our results, we conclude that the increase in general FROH and Fped signifcantly decreases TO and VO; however, in diferent chromosomes traits can increase or decrease with FROH. In the analysis for signatures of selection, we identifed 15 genes from 47 signifcant genomic regions, indicating diferences in populations with high and low breeding value for the three traits.  aBovino  aEmbrião Animal  aGado Gir  aHomozigose  aOvócito1 aGARCIA, A. O.1 aOTTO, P. I.1 aSILVA, M. V. G. B.1 aMARTINS, M. F.1 aMACHADO, M. A.1 aPANETTO, J. C. do C.1 aGUIMARÃES, S. E. F.  tMammalian Genomegv. 34, p. 482-496, 2023.