02281naa a2200385 a 450000100080000000500110000800800410001902400360006010000160009624501420011226000090025452011530026365300120141665300300142865300260145865300270148465300080151170000150151970000260153470000160156070000190157670000200159570000240161570000190163970000210165870000230167970000190170270000200172170000220174170000160176370000200177970000190179970000260181877300510184421521952023-03-08       2022    bl uuuu     u00u1 u    #d7 a10.1007/s00335-022-09969-62DOI1 aBUSS, C. E.  aBivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle.h[electronic resource]  c2022  aFeed-efcient cattle selection is among the most leading solutions to reduce cost for beef cattle production. However, technical difculties in measuring feed efciency traits had limited the application in livestock. Here, we performed a Bivariate Genome-Wide Association Study (Bi-GWAS) and presented candidate biological mechanisms underlying the association between feed efciency and meat quality traits in a half-sibling design with 353 Nelore steers derived from 34 unrelated sires. A total of 13 Quantitative Trait Loci (QTL) were found explaining part of the phenotypic variations. An important transcription factor of adipogenesis in cattle, the TAL1 (rs133408775) gene located on BTA3 was associated with intramuscular fat and average daily gain (IMF-ADG), and a region located on BTA20, close to CD180 and MAST4 genes, both related to fat accumulation. We observed a low positive genetic correlation between IMF-ADG (r=0.30±0.0686), indicating that it may respond to selection in the same direction. Our fndings contributed to clarifying the pleiotropic modulation of the complex traits, indicating new QTLs for bovine genetic improvement.  aBi GWAS  aEfciency and meat quality  aPhenotypic variations  aPleiotropic modulation  aQTL1 aAFONSO, J.1 aOLIVEIRA, P. S. N. DE1 aPETRINI, J.1 aTIZIOTO, P. C.1 aCESAR, A. S. M.1 aGUSTANI-BUSS, E. C.1 aCARDOSO, T. F.1 aROVADOSKI, G. A.1 aDINIZ, W. J. DA S.1 aLIMA, A. O. DE1 aROCHA, M. I. P.1 aANDRADE, B. G. N.1 aWOLF, J. B.1 aCOUTINHO, L. L.1 aMOURÃO, G. B.1 aREGITANO, L. C. de A.  tMammalian Genomegv. 34, p. 90-103, dec. 2022.