02646naa a2200493 a 450000100080000000500110000800800410001902400450006010000190010524501110012426000090023530000100024452013060025465000200156065000150158065000180159565300170161365300150163065300190164565300250166465300110168970000230170070000170172370000220174070000220176270000220178470000190180670000150182570000140184070000150185470000150186970000260188470000190191070000260192970000170195570000160197270000200198870000170200870000190202570000220204470000230206670000200208977300430210921459982022-09-01       2022    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.3390/ani121316322DOI1 aFINALLI, S. L.  aDifferential gene expression associated with soybean oil level in the diet of pigs.h[electronic resource]  c2022  a21 p.  aThe aim of this study was to identify the differentially expressed genes (DEG) from the skeletal muscle and liver samples of animal models for metabolic diseases in humans. To perform the study, the fatty acid (FA) profile and RNA sequencing (RNA-Seq) data of 35 samples of liver tissue (SOY1.5, n = 17 and SOY3.0, n = 18) and 36 samples of skeletal muscle (SOY1.5, n = 18 and SOY3.0, n = 18) of Large White pigs were analyzed. The FA profile of the tissues was modified by the diet, mainly those related to monounsaturated (MUFA) and polyunsaturated (PUFA) FA. The skeletal muscle transcriptome analysis revealed 45 DEG (FDR 10%), and the functional enrichment analysis identified network maps related to inflammation, immune processes, and pathways associated with oxidative stress, type 2 diabetes, and metabolic dysfunction. For the liver tissue, the transcriptome profile analysis revealed 281 DEG, which participate in network maps related to neurodegenerative diseases. With this nutrigenomics study, we verified that different levels of soybean oil in the pig diet, an animal model for metabolic diseases in humans, affected the transcriptome profile of skeletal muscle and liver tissue. These findings may help to better understand the biological mechanisms that can be modulated by the diet.  aImmune response  aMetabolism  aTranscriptome  aAnimal model  aFatty acid  aHepatic tissue  aLongissimus lomborum  aRNAseq1 aSILVA, B. P. M. DA1 aGOMES, J. D.1 aALMEIDA, V. V. DE1 aFREITAS, F. A. O.1 aMOREIRA, G. C. M.1 aVIGNATO, B. S.1 aAFONSO, J.1 aREECY, J.1 aKOLTES, J.1 aKOLTES, D.1 aREGITANO, L. C. de A.1 aGARRICK, D. J.1 aBALIEIRO, J. C. DE C.1 aMEIRA, A. N.1 aFREITAS, L.1 aCOUTINHO, L. L.1 aFUKUMASU, H.1 aMOURÃO, G. B.1 aALENCAR, S. M. DE1 aLUCHIARI FILHO, A.1 aCESAR, A. S. M.  tAnimalsgv. 12, n. 13 1632, jun. 2022.