02791naa a2200469 a 450000100080000000500110000800800410001902400520006010000190011224501450013126000090027630000100028552013820029565000210167765000180169865300370171665300240175365300260177765300290180365300220183265300430185470000230189770000170192070000210193770000220195870000220198070000220200270000190202470000150204370000140205870000150207270000150208770000260210270000260212870000160215470000200217070000170219070000220220770000230222970000200225277300490227221459652022-09-01       2022    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1038/s41598-022-14069-12DOI1 aFANALLI, S. L.  aEffect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases.h[electronic resource]  c2022  a10 p.  aDietary fatty acids (FA) are components of the lipids, which contribute to membrane structure, energy input, and biological functions related to cellular signaling and transcriptome regulation. However, the consumers still associate dietary FA with fat deposition and increased occurrence of metabolic diseases such as obesity and atherosclerosis. Previous studies already demonstrated that some fatty acids are linked with inflammatory response, preventing metabolic diseases. To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. The key TF were identified by functional enrichment analysis from the list of differentially expressed genes identified in liver samples between 35 pigs fed with 1.5% or 3.0% soybean oil. The functional enrichment analysis detected TF linked to lipid homeostasis and inflammatory response, such as RXRA, EGFR, and SREBP2 precursor. These findings demonstrated that key TF related to lipid metabolism could be modulated by dietary inclusion of soybean oil. It could contribute to nutrigenomics research field that aims to elucidate dietary interventions in animal and human health, as well as to drive food technology and science.  aLipid metabolism  aNutrigenomics  aDietary FA on metabolic diseases  aDietary fatty acids  aDietary interventions  aHuman metabolic diseases  aLipid homeostasis  aTranscriptome profile of animal models1 aSILVA, B. P. M. DA1 aGOMES, J. D.1 aCICONELLO, F. N.1 aALMEIDA, V. V. DE1 aFREITAS, F. A. O.1 aMOREIRA, G. C. M.1 aVIGNATO, B. S.1 aAFONSO, J.1 aREECY, J.1 aKOLTES, J.1 aKOLTES, D.1 aREGITANO, L. C. de A.1 aBAILEIRO, J. C. DE C.1 aFREITAS, L.1 aCOUTINHO, L. L.1 aFUKUMASU, H.1 aALENCAR, S. M. DE1 aLUCHIARI FILHO, A.1 aCESAR, A. S. M.  tScientific Reportsgv. 12, 10318, jun. 2022.