02437naa a2200349 a 450000100080000000500110000800800410001902400550006010000220011524501450013726000090028252013880029165000110167965000100169065000140170065000110171465000220172565300170174765300250176470000170178970000210180670000210182770000240184870000230187270000160189570000190191170000230193070000190195370000250197270000190199777300710201621448932022-07-25       2022    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1080/09712119.2022.20960352DOI1 aSANTOS, C. G. dos  aCandidate genes for tick resistance in cattleba systematic review combining post-GWAS analyses with sequencing data.h[electronic resource]  c2022  aRhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5' UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses.  aBovino  aCarne  aCarrapato  aGenoma  aHospedeiro Animal  aEctoparasita  aSistema imunológico1 aSOUSA, M. F.1 aVIEIRA, J. I. G.1 aMORAIS, L. R. de1 aFERNANDES, A. A. S.1 aLITTIERE, T. de O.1 aOTTO, P. I.1 aMACHADO, M. A.1 aSILVA, M. V. G. B.1 aBONAFÉ, C. M.1 aMAGALHÃES, A. F. B.1 aVERARDO, L. L.  tJournal of Applied Animal Researchgv. 50, n. 1, p. 460-470, 2022.