02506naa a2200397 a 450000100080000000500110000800800410001902200140006002400540007410000160012824501130014426000090025750000390026652014000030565000110170565000170171665000160173365000090174965000150175865300100177365300260178365300190180965300120182870000200184070000180186070000170187870000250189570000180192070000210193870000230195970000250198270000180200770000170202570000200204277300460206221442182022-06-21       2022    bl uuuu     u00u1 u    #d  a0093-691X7 adoi.org/10.1016/j.theriogenology.2022.02.0102DOI1 aHAAS, C. S.  aBone morphogenetic protein 15 intrafollicular injection inhibits ovulation in cattle.h[electronic resource]  c2022  aAvailable online 10 February 2022.  aOocyte-derived bone morphogenetic protein 15 (BMP15) is one of the main local regulators of ovarian physiology, but its role in the regulation of preovulatory follicles and ovulation is not well established. Therefore, this study was conceived to determine the effect of intrafollicular injection (IFI) of BMP15 on final follicular growth, ovulation and luteinization in cattle. Initially, it was observed that relative mRNA abundance of the BMP15 receptor BMPR1B in granulosa cells was regulated by GnRH treatment, and it was negatively correlated (R2 = 0.5; P &lt 0.001) to progesterone concentration in follicular fluid (FF) from preovulatory follicles. The IFI of recombinant human BMP15 tended to inhibit the growth of dominant follicles, as evidenced by an average increase of only 7.7% in the follicular diameter (from 8.8 mm to 9.1 mm) at 36 h post injection compared to 36.4% increase (from 8.9 mm to 14 mm) in the control group. Injection of BMP15 into preovulatory follicles (12?14 mm), simultaneously to im GnRH treatment, inhibited ovulation compared to control group, but did not prevent luteinization and progesterone production. Most of preovulatory follicles injected with BMP15 became luteinized cysts. Collectively, these findings indicate a suppressive role of BMP15 on later follicular development and ovulation in cattle, but not on luteogenesis and progesterone secretion.  aBovino  aCorpo Lúteo  aFertilidade  aGado  aOvulação  aBMP15  aCrescimento folicular  aLuteinização  aOócito1 aOLIVEIRA, F. C.1 aROVANI, M. T.1 aFERST, J. G.1 aVARGAS JUNIOR, S. F.1 aVIEIRA, A. D.1 aMONDADORI, R. G.1 aPEGORARO, L. M. C.1 aGONÇALVES, P. B. D.1 aBORDIGNON, V.1 aFERREIRA, R.1 aGASPERIN, B. G.  tTheriogenologygv. 182, p. 148-154, 2022.