02161naa a2200409 a 450000100080000000500110000800800410001902400480006010000180010824500920012626000090021852010240022765000200125165000160127165000240128765000140131165300170132565300230134265300130136565300140137870000230139270000230141570000200143870000120145870000150147070000200148570000240150570000210152970000170155070000170156770000200158470000250160470000230162970000260165270000200167877300530169821357632021-11-03       2021    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1002/cbdv.2021004392DOI1 aTORRES, D. S.  aSynthetic auronesbnew features for Schistosoma mansoni therapy.h[electronic resource]  c2021  aIn this work, two synthetic aurones revealed moderate schistosomicidal potential in in vitro and in vivo assays. Aurones (1) and (2) promoted changes in tegument integrity and motor activity, leading to death of adult Schistosoma mansoni worms in in vitro assays. When administered orally (two doses of 50mg/kg) in experimentally infected animals, synthetic aurones (1) and (2) promoted reductions of 56.20% and 57.61% of the parasite load and stimulated the displacement towards the liver of the remaining adult worms. The oogram analysis revealed that the treatment with both aurones interferes with the egg development kinetics in the intestinal tissue. Seeking an action target for compounds (1) and (2), the connection with NTPDases enzymes, recognized as important therapeutic targets for S. mansoni, was evaluated. Molecular docking studies have shown promising results. The dataset reveals the anthelmintic character of these compounds, which can be used in the development of new therapies for schistosomiasis.  aEsquistossomose  aFlavonóide  aSchistosoma Mansoni  aVerminose  aAnthelmintic  aChistosoma mansoni  aNTPDases  aSmATPDase1 aOLIVEIRA, B. A. de1 aSILVEIRA, L. S. da1 aSILVA, M. P. da1 aPEREIRA1 aMORAES, J.1 aCOURI, M. R. C.1 aQUEIROZ, R. F. G. e1 aPARREIRAS, P. M.1 aSILVA, M. R.1 aALVES, L. A.1 aSOUZA, V. C. de1 aGOLIATT, P. V. Z. C.1 aVASCONCELOS, E. G.1 aSILVA FILHO, A. A. da1 aPINTO, P. de F.  tChemistry & Biodiversitygv. 18, e2100439, 2021.