02091naa a2200349 a 450000100080000000500110000800800410001902200140006002400390007410000200011324502000013326000090033330000090034252010460035165000120139765000210140965000100143065300170144065300150145765300260147270000210149870000160151970000200153570000210155570000150157670000190159170000170161070000190162770000220164670000220166877300510169021307332022-06-10       2020    bl uuuu     u00u1 u    #d  a1744-41607 a10.1080/13813455.2020.17437232DOI1 aOLIVEIRA, P. S.  aBrazilian native fruit extracts act as preventive agents modulating the purinergic and cholinergic signalling in blood cells and serum in a rat model of metabolic syndrome.h[electronic resource]  c2020  a8 p.  aIn this study, we evaluated the effects of native fruit extracts on inflammatory and thromboregulatory parameters in animal model of metabolic syndrome (MetS) induced by highly palatable diet (HPD). Rats were divided into 4 experimental groups: standard chow, HPD, HPD and Psidium cattleianum extract, and HPD and Eugenia uniflora extract. HPD increased serum interleukin-6 (IL-6) levels. On the other hand, this change was prevented by extracts. HPD decreased NTPDase activity in lymphocytes and platelets and 50-nucleotidase in platelets. Treatment with extracts prevented these changes. An increase in adenosine deaminase (ADA) activity was prevented by E. uniflora in lymphocytes and serum of rats. Fruit extracts prevented the increase in the activity of acetylcholinesterase (AChE) in lymphocytes and butyrylcholinesterase (BuChE) in serum induced by the HPD. Brazilian native fruit extracts have anti-inflammatory and antithrombotic effects, demonstrating therapeutic potential in the prevention of complications associated with MetS.  aExtrato  aExtrato de Fruta  aFruta  aFruta nativa  aRed fruits  aSíndrome metabólica1 aSOARES, M. S. P.1 aBONA, N. P.1 aSILVA, P. G. DA1 aMENDONÇA, L. T.1 aVIEIRA, A.1 aDAL-PIZZOL, F.1 aVIZZOTTO, M.1 aLENCINA, C. L.1 aSPANEVELLO, R. M.1 aSTEFANELLO, F. M.  tArchives of Physiology and Biochemistry, 2020.