02543naa a2200373 a 450000100080000000500110000800800410001902200140006002400350007410000250010924501840013426000090031852013970032765000250172465000210174965000160177065000100178665000150179665000080181165300270181965300230184665300210186970000170189070000250190770000230193270000310195570000200198670000220200670000200202870000190204870000210206770000280208877300530211621208032020-10-13       2019    bl uuuu     u00u1 u    #d  a1436-62077 a0.1007/s00394-019-02139-62DOI1 aTOSCANO, L. de L. T.  aA single dose of purple grape juice improves physical performance and antioxidant activity in runnersba randomized, crossover, double?blind, placebo study.h[electronic resource]  c2019  aPurposeTo investigate the effects of a single dose of juice on physical performance, oxidative stress, inflammation and muscle damage in runners.Methods Fourteen recreational male runners (39 ± 9 years, VO2peak = 55.9 ± 6.5 ml/kg/min) performed two running tests to exhaustion at 80% of VO2max after ingesting grape juice or a placebo drink (10 ml/kg/day) randomly. Blood samples were taken before and 2 h after supplementation and immediately after running to analyze total antioxidant capacity (TAC), malondialdehyde (MDA), alpha-1 acid glycoprotein (A1GPA), high-sensitivity C-reactive protein (hs-CRP), creatine kinase (CK) and lactate dehydrogenase (LDH).ResultsThe participants ran for an average of 59.2 ± 27.8 min until exhaustion in the placebo group and for 68.4 ± 29.7 min until exhaustion in the grape juice intake group, which was a significantly longer time (p = 0.008). This improvement in physical performance was accompanied by a 43.6% increase in TAC (p = 0.000) at the post-exercise timepoint compared to the level at baseline. MDA, A1GPA, hs-CRP, CK, and LDH did not exhibit changes. In contrast, no significant change in any variable was observed after consuming the placebo drink.ConclusionThe single-dose intake of purple grape juice demonstrated an ergogenic effect in recreational runners by increas-ing run time to exhaustion and increasing antioxidant activity.  aAthletic performance  aOxidative stress  aPolyphenols  aDieta  aNutrição  aUva  aAtividade antioxidante  aDesempenho físico  aSumo de uva roxa1 aSILVA, A. S.1 aFRANÇA, A. C. L. de1 aSOUSA, B. R. V. de1 aALMEIDA FILHO, E. J. B. de1 aCOSTA, M. da S.1 aBIASOTO, A. C. T.1 aSILVA, D. F. da1 aSENA, K. de F.1 aCERQUEIRA, G. S.1 aGONÇALVES, M. da C. R.  tEuropean Journal of Nutritiongv. 58, nov. 2019.