02644naa a2200481 a 450000100080000000500110000800800410001902400320006010000180009224501120011026000090022252012840023165000200151565000220153565000120155765000190156965000130158865000110160170000200161270000200163270000170165270000240166970000180169370000150171170000150172670000220174170000190176370000200178270000230180270000170182570000190184270000170186170000210187870000180189970000190191770000260193670000220196270000170198470000210200170000200202270000170204277301030205921202162020-02-13       2019    bl uuuu     u00u1 u    #d7 a10.3390/ijerph161526792DOI1 aVIEIRA, Y. R.  aEvaluation of HBV-Like circulation in wild and farm animals from Brazil and Uruguay.h[electronic resource]  c2019  aThe origin of the hepatitis B virus is a subject of wide deliberation among researchers. As a result, increasing academic interest has focused on the spread of the virus in different animal species. However, the sources of viral infection for many of these animals are unknown since transmission may occur from animal to animal, human to human, animal to human, and human to animal. The aim of this study was to evaluate hepadnavirus circulation in wild and farm animals (including animals raised under wild or free conditions) from different sites in Brazil and Uruguay using serological and molecular tools. A total of 487 domestic wild and farm animals were screened for hepatitis B virus (HBV) serological markers and tested via quantitative and qualitative polymerase chain reaction (PCR) to detect viral DNA. We report evidence of HBsAg (surface antigen of HBV) and total anti-HBc (HBV core antigen) markers as well as low-copy hepadnavirus DNA among domestic and wild animals. According to our results, which were confirmed by partial genome sequencing, as the proximity between humans and animals increases, the potential for pathogen dispersal also increases. A wider knowledge and understanding of reverse zoonoses should be sought for an effective One Health response.  aAnimal diseases  aHepatitis B virus  aViruses  aDoença Animal  aHepatite  aVírus1 aPORTILHO, M. M.1 aOLIVEIRA, F. F.1 aGUTERRES, A.1 aSANTOS, D. R. L dos1 aVILLAR, l. M.1 aMIRAZO, S.1 aARBIZA, J.1 aDIMACHE, L. A. G.1 aALMEIDA, F. Q.1 aBRANDÃO, M. L.1 aCORDEIRO, J. L. P.1 aROCHA, F. L.1 aAZEVEDO, F. C.1 aLEMOS, F. G.1 aCAMPOS, J. B. V.1 aMACEDO, G. C.1 aHERRERA, H. M.1 aPERES, I. A. H. F. S.1 aZIMMERMANN, N. P.1 aPIOVEZAN, U.1 aPELLEGRIN, A. O.1 aPAULA, V. S. de1 aPINTO, M. A.  tInternational Journal of Environmental Research and Public Healthgv. 16, n. 15, e2679, jul. 2019.