02468naa a2200409 a 450000100080000000500110000800800410001902400550006010000210011524501340013626000090027052012550027965000170153465000170155165000120156865000130158065000200159365000270161365000230164065300230166365300260168665300190171265300170173165300150174870000190176370000210178270000170180370000200182070000200184070000220186070000180188270000200190070000230192070000220194370000180196577300750198321193162023-01-12       2020    bl uuuu     u00u1 u    #d7 ahttp://dx.doi.org/10.21577/0103-5053.201902422DOI1 aCASTRO, C. B. DE  aMetabolomics-based discovery of biomarkers with cytotoxic potential in extracts of Myracrodruon urundeuva.h[electronic resource]  c2020  aMyracrodruon urundeuva (aroeira-do-sertão) is a species threatened with extinction due to anthropogenic exploitation. Phytochemical analysis of bark, branch and leaf extracts revealed the presence of several compounds such as flavonoids, phenols, tannins, quercetin derivatives and anacardic acids. Dereplication methodology was performed to tentatively identify 50 compounds analyzed by ultra-performance liquid chromatography coupled with an electrospray ionization quadrupole time-of-flight mass spectrometry operating in MSE mode (UPLC-QTOF-MSE). The extracts exhibited anti-tumor effect in cancer cells HCT-116 (colorectal), SF-295 (glioblastoma), HL-60 (leukemia), and RAJI (leukemia). Also, these results correlate with the principal component analysis (PCA) data that identified three distinct groups indicating, efficiently, metabolic differences between organs of M. urundeuva. Through discriminatory analysis of the orthogonal partial least squares (OPLS-DA), the variable of importance in the projection (VIP) and S-Plot, we were able to determine 30 potential biomarkers. The fingerprint of hydroethanolic extracts was correlated with the cytotoxicity assay and demonstrated a significant difference in the composition of plant extract.  aChemometrics  aCytotoxicity  aAroeira  aCaatinga  aEspécie Nativa  aMyracrodruon Urundeuva  aVegetação Nativa  aAroeira do sertão  aAtividade citotóxica  aBioma Caatinga  aQuimiometria  aUPLC-MS/MS1 aLUZ, L. DOS R.1 aGUEDES, J. A. C.1 aPORTO, D. D.1 aSILVA, M. F. S.1 aSILVA, G. S. DA1 aRIBEIRO, P. R. V.1 aCANUTO, K. M.1 aBRITO, E. S. de1 aZAMPIERI, D. DE S.1 aPESSOA, C. do Ó.1 aZOCOLO, G. J.  tJournal of the Brazilian Chemical Societygv. 31, n. p. 775-787, 2020.