02225naa a2200361 a 450000100080000000500110000800800410001902200140006002400380007410000200011224501630013226000090029552011340030465000100143865000140144865000250146265000120148765000150149965000230151465000260153765000110156370000190157470000200159370000140161370000220162770000210164970000190167070000200168970000220170970000210173170000220175277300890177421165832020-04-20       2020    bl uuuu     u00u1 u    #d  a0939-47537 a10.1016/j.numecd.2019.07.0202DOI1 aGOMES, M. J. C.  aCommon bean protein hydrolysate modulates lipid metabolism and prevents endothelial dysfunction in BALB/c mice fed an atherogenic diet.h[electronic resource]  c2020  aBackground and aims: Common beans (Phaseolus vulgaris L.) protein hydrolysate is a source of bioactive peptides with known health benefits. The aim of this study was to evaluate the effect of common bean protein hydrolysate on lipid metabolism and endothelial function in male adult BALB/c mice fed an atherogenic diet for nine weeks. Methods and results: Male adult mice were divided into three experimental groups (n = 12) and fed with normal control diet; atherogenic diet and atherogenic diet added with bean protein hydrolysate (700 mg/kg/day) for nine weeks. Food intake, weight gain, lipid profile, Atherogenic Index of Plasma, inflammation biomarkers and endothelial function were evaluated. APH group presented reduced feed intake, weight gain, lipid profile, tumor necrosis factor-a, angiotensin II (94% and 79%, respectively) and increased endothelial nitric oxide synthase (62%). Conclusions: Protein hydrolysate showed hypocholesterolemic activity preventing inflammation and dysfunction of vascular endothelium, in addition to decreasing oxidative stress, indicating an adjuvant effect on reducing atherogenic risk.  aBeans  aNutrition  aProtein hydrolysates  aFeijão  aNutrição  aPhaseolus Vulgaris  aProteína Hidrolisada  aSaúde1 aLIMA, S. L. S.1 aALVES, N. E. G.1 aASSIS, A.1 aMOREIRA, M. E. C.1 aTOLEDO, R. C. L.1 aROSA, C. O. B.1 aTEIXEIRA, O. R.1 aBASSINELLO, P. Z.1 aMEJÍA, E. G. de1 aMARTINO, H. S. D.  tNutrition, Metabolism & Cardiovascular Diseasesgv. 30, n. 1, p. 141-150, Jan. 2020.