02473naa a2200433 a 450000100080000000500110000800800410001902400520006010000150011224501430012726000090027052012150027965000200149465000160151465000170153065000180154765000160156565000340158165300270161565300160164265300110165865300230166970000200169270000190171270000230173170000190175470000200177370000160179370000250180970000140183470000170184870000160186570000200188170000260190170000210192770000190194870000260196777300460199321154862023-03-13       2019    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1038/s41598-019-49089-x2DOI1 aAFONSO, J.  aMuscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indicus.h[electronic resource]  c2019  aMineral content affects the biological processes underlying beef quality. Muscle mineral concentration depends not only on intake-outtake balance and muscle type, but also on age, environment, breed, and genetic factors. To unveil the genetic factors involved in muscle mineral concentration, we applied a pairwise diferential gene expression analysis in groups of Nelore steers genetically divergent for nine diferent mineral concentrations. Here, based on signifcant expression diferences between contrasting groups, we presented candidate genes for the genetic regulation of mineral concentration in muscle. Functional enrichment and protein-protein interaction network analyses were carried out to search for gene regulatory processes concerning each mineral. The core genetic regulation for all minerals studied, except Zn, seems to rest on interactions between components of the extracellular matrix. Regulation of adipogenesis-related pathways was also signifcant in our results. Antagonistic patterns of gene expression for fatty acid metabolism-related genes may explain the Cu and Zn antagonistic efect on fatty acid accumulation. Our results shed light on the role of these minerals on cell function  aAnimal breeding  aBeef cattle  aBeef quality  aGado de Corte  aGado Nelore  aMelhoramento Genético Animal  aMineral concentrations  aMuscle type  aNelore  aQualidade da carne1 aCOUTINHO, L. L.1 aTIZIOTO, P. C.1 aDINIZ, W. J. da S.1 aLIMA, A. O. de1 aROCHA, M. I. P.1 aBUSS, C, E.1 aANDRADE, B. G. N. A.1 aPIAYA. O.1 aSILVA, J. V.1 aLINS, L. A.1 aGROMBONI, C. F.1 aNOGUEIRA, A. R. de A.1 aFORTES, M. R. S.1 aMOURÃO, G. B.1 aREGITANO, L. C. de A.  tScientific Reportsgv. 9, n. 12715, 2019.