01940naa a2200325 a 450000100080000000500110000800800410001902400570006010000170011724501100013426000090024452009430025365000230119665000330121965000120125265000240126465000220128865000140131065000270132465300170135165300190136865300200138770000180140770000280142570000210145370000210147470000190149570000150151477300850152921149572019-11-22       2019    bl uuuu     u00u1 u    #d7 ahttp://dx.doi.org/10.1590/0001-37652019201805982DOI1 aPAZIN, W. M.  aBioactivity and action mechanism of green propolis against Pythium aphanidermatum.h[electronic resource]  c2019  aAbstract: We have established how natural compounds from green propolis collected by the species Apis mellifera act against the growth of Pythium aphanidermatum. On the basis of mass spectrometry (Q-ToF MS), we determined that Artepillin C, the major constituent of green propolis, underlies the effect and displays activity against P. aphanidermatum at a minimal inhibitory concentration of 750 ?g.ml-1. Biophysical studies based on model membranes showed that this inhibitory effect may be linked with a membrane-related phenomenon: Artepillin C increases the permeability of membranes with relatively high fluidity in their lateral structure, a feature that is in line with the lipid composition reported for the cytoplasmic membrane of P. aphanidermatum. Therefore, the present study supports the use of the effective and inexpensive green propolis to control the impact of the dangerous phytopathogen P. aphanidermatumon agriculture.  aBiological control  aPlant diseases and disorders  aPythium  aControle biológico  aDoença de Planta  aPrópolis  aPythium aphanidermatum  aArtepillin C  aGreen propolis  aModel membranes1 aSANTOS, S. N.1 aQUEIROZ, S. C. do N. de1 aBAGATOLLI, L. A.1 aSOARES, A. E. E.1 aMELO, I. S. de1 aITO, A. S.  tAnais da Academia Brasileira de Ciênciasgv. 91, n. 2, 2019. Article e20180598.