01768naa a2200277 a 450000100080000000500110000800800410001902400340006010000200009424501680011426000090028252009010029165000150119265000140120765000100122165300250123165300240125670000250128070000190130570000210132470000220134570000210136770000220138870000220141077300580143221095112020-01-24       2019    bl uuuu     u00u1 u    #d7 a10.1016/j.j?.2019.05.0092DOI1 aSOUSA, A. R. de  aExtruded sorghum (Sorghum bicolor L.) improves gut microbiota, reduces inflammation, and oxidative stress in obese rats fed a high-fat diet.h[electronic resource]  c2019  aThe aim of this study was to investigate the e?ects of extruded sorghum ?our (ESF) on rats fed with a high-fat diet(HFD)ongutmicrobiotamodulation, in?ammation,andoxidativestress.MaleWistar ratswerefedanormal diet (AIN-93M, n=8), HFD (n=8), or HFD plus ESF replacing 50% cellulose and 100% corn starch (HFDS50, n=8) or HFD plus ESF replacing 100% cellulose and 100% corn starch (HFDS100, n=8) for eight weeks. ESF improved the composition of intestinal microbiota by increasing the proportion of the Bacteroidetes phylum instead of the Firmicutes phylum. Furthermore, ESF reduced the concentrations of p65 NF-?B in liver, seric resistin, lipids peroxidation and increase the total antioxidant capacity of plasma, the expression of superoxide dismutase, andthe heatshockprotein72. Inconclusion, ESFimprovestheintestinaldysbiosis, in?ammationand oxidative stress in obese rats fed a hyperlipid diet.  aFirmicutes  aObesidade  aSorgo  aDieta hiperlipídica  aDisbiose intestinal1 aMOREIRA, M. E. de C.1 aGRANCIERIA, M.1 aTOLEDO, R. C. L.1 aARAÚJO, F. de O.1 aMANTOVANI, H. C.1 aQUEIROZ, V. A. V.1 aMARTINO, H. S. D.  tJournal of Functional Foodsgv. 58, p. 282-291, 2019.