01862naa a2200253 a 450000100080000000500110000800800410001910000200006024501500008026000090023052010900023965000160132965000140134565300190135965300220137870000250140070000210142570000240144670000220147070000180149270000190151070000220152977300570155121063252019-02-21       2018    bl uuuu     u00u1 u    #d1 aSOUSA, A. R. de  aExtruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet.h[electronic resource]  c2018  aThe study investigated the effect of extruded sorghum flour (ESF) in a high fat diet (HFD) on biometric measurements and hepatic lipogenesis. Male Wistar rats were fed a normal diet (AIN-93M), HFD, HFD plus ESF replacing 50% cellulose and 100% corn starch (HFDS50), or HFD plus ESF replacing 100% cellulose and 100% corn starch (HFDS100) for eight weeks. ESF reduced the body mass index and liver weight of obese rats. Additionally, ESF reduced hepatic lipogenesis by increasing adiponectin 2 receptor gene expression and gene and protein expressions of peroxisome proliferator-activated receptor (PPAR), while reducing the gene expression of sterol regulatory element-binding transcription factor 1. Molecular docking analysis revealed the a?nity of ESF compounds (luteolinidin, apigeninidin, 5-methoxy-luteolinidin, and 7-methoxy-apigeninidin) with the PPAR-?receptor. Histological analysis con?rmed the decreased grade of hepatic steatosis in obese rats. These data indicate the potential of ESF to reduce metabolic risk of hepatic steatosis associated with lipogenesis and obesity.  aAntocianina  aEsteatose  aAdipogenética  aComposto bioativo1 aMOREIRA, M. E. de C.1 aTOLEDO, R. C. L.1 aBENJAMIN, L. dos A.1 aQUEIROZ, V. A. V.1 aVELOSO, M. P.1 aREIS, K. de S.1 aMARTINO, H. S. D.  tFood Research Internationalgv. 112, p. 48-55, 2018.