01856nam a2200301 a 450000100080000000500110000800800410001910000210006024501630008126002280024452007640047265000200123665000090125665000120126565000260127765000100130365000210131365000100133465000240134465000310136870000250139970000170142470000210144170000230146270000220148570000200150770000270152720951582019-09-23       2018    bl uuuu     u00u1 u    #d1 aBRAGANÇA, G. M.  aThe use of different progestin devices in ovarian stimulation protocol affects gene expression in sheep cumulus-oocyte complexes (COC).h[electronic resource]  aAnimal Reprodroduction, v. 15, n. 3, p. 591, Jul./Sept. 2018. Abstracts A276E. Edição dos Proceedings of the 34rd Meeting of the Association of Embryo Transfer in Europe (AETE); Nantes, France, September 7th and 8thc2018  aProgesterone (P4) and its analogues (progestins) are commonly used in estrus synchronization protocols and to hold the LH surge during ovarian stimulation to allow oocyte recovery in live donor ewes. However, recent evidence suggests that some progestins may have a deleterious effect on embryo quality after long-term use. Thus, the present study aimed to evaluate the effect of two progestin devices used during ovarian stimulation on the COC quality in donor ewes.  In conclusion, the progestin device alters the expression of genes related to quality and the steroidogenesis pathway in fully-grown COCs, and the use of a natural P4 device may improve the development competence of COCs. Further studies including IVP are necessary to confirm our findings.  aEmbryo transfer  aEwes  aOocytes  aProgestogen receptors  aSheep  aSteroid hormones  aOvino  aReprodução Animal  aTransferência de Embrião1 aBATISTA, R. I. T. P.1 aSOUZA, C. V.1 aSANTOS, J. D. R.1 aARASHIRO, E. K. N.1 aFONSECA, J. F. da1 aBRANDÃO, F. Z.1 aSOUZA-FABJAN, J. M. G.