01972nam a2200205 a 450000100080000000500110000800800410001910000200006024501400008026001120022050000280033252012510036065000300161170000200164170000200166170000290168170000200171070000170173070000190174720916612023-06-06       2018    bl uuuu     u00u1 u    #d1 aROMUALDO, G. R.  aThe effects of anthocyanin-rich Myrtaceae fruits peel powder on fibrosis-associated hepatocarcinogenesisin mice.h[electronic resource]  aIn: WORLD TOXICOLOGIC PATHOLOGY CONGRESS, 2018, São Paulo. [Anais... São Paulo: Galoá, 2018] 4. p.c2018  aWTPC. 21 a 26 de abril.  aFruits from Myrtaceae family, as jabuticaba (Myrciaria jaboticaba (Vell) O. Berg), jamelão (Syzygium cumini (L.) Skeels) and jambo (Syzygium malaccense), raise interest due to their high levels of anthocyanins, antioxidant compounds, and, thus, potential for chronic disease risk reduction¹. Therefore, the study evaluated whether the ingestion of jabuticaba, jamelão or jambo peel powder attenuates fibrosis-associated hepatocarcinogenesis. Neonatal female C3H/Hej mice were submitted to a diethylnitrosamine (DEN)/carbon tetrachloride (CCl4)-induced fibrosis-associated hepatocarcinogenesis model. Mice also received basal diet or basal diet containing 2% of jabuticaba, jamelão or jambo dehydrated peels for 10 weeks. HPLC analysis of dehydrated fruit peels revealed high levels of anthocyanins in jabuticaba (802.89±22.88 mg/100g), jamelão (575.95±9.42 mg/100g) and jambo (156.05±10.39 mg/100g). These fruits displayed different types of anthocyanins (Figures 1-3). Interestingly, only the ingestion of basal diet containing jamelão peel powder attenuated liver fibrosis compared to DEN/CCl4 (Figure 4). Mechanisms will be evaluated, as well as the effects of these fruits on the development of preneoplasic/neoplastic liver lesions.  aProduto de Origem Vegetal1 aSOUZA, I. P. de1 aSOUZA, L. V. de1 aSANTIAGO, M. C. P. de A.1 aBORGUINI, R. G.1 aCOGLIATI, B.1 aBARBISAN, L. F