01843naa a2200445 a 450000100080000000500110000800800410001902400350006010000310009524501630012626000090028952005650029865000120086365000210087565000090089665000200090565000210092565000200094665300140096665300190098065300080099965300180100765300130102565300130103865300180105165300160106970000210108570000170110670000230112370000170114670000170116370000220118070000200120270000200122270000200124270000190126270000280128170000280130977300600133720909042018-05-02       2018    bl uuuu     u00u1 u    #d7 a10.1016/j.jep.2018.04.0092DOI1 aOLIVEIRA JÚNIOR, R. G. de  aNeuropharmacological effects of essential oil from the leaves of Croton conduplicatus Kunth and possible mechanisms of action involved.h[electronic resource]  c2018  aEthnopharmacological relevance: Croton conduplicatus Kunth (Euphorbiaceae) is a Brazilian aromatic medicinal plant, widely known as ?quebra-faca?. In folk medicine, its leaves and stem-barks are used as a natural analgesic for the treatment of headaches. Aim of the study: In this study, we describe for the first time the neuropharmacological potential of the essential oil obtained from the leaves of Croton conduplicatus (EO) in experimental models of pain, anxiety and insomnia. The mechanisms of action involved in these activities were also investigated.  aAnxiety  aMedicinal plants  aPain  aÓleo essencial  aPlanta medicinal  aRecurso natural  aAnsiedade  aBioma Caatinga  aDor  aEssential oil  aInsomnia  aInsônia  aPlanta nativa  aQuebra faca1 aFERRAZ, C. A. A.1 aSILVA, J. C.1 aTELES. R. B. de A.1 aSILVA, M. G.1 aDINIZ, T. C.1 aSANTOS, U. S. dos1 aSOUZA, A. V. de1 aNUNES, C. E. P.1 aSALVADOR, M. J.1 aLORENZO, V. P.1 aQUINTANS JÚNIOR, L. J.1 aALMEIDA, J. R. G. da S.  tJournal of Ethnopharmacologygv. 221, p. 65–76, 2018.